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3.A.3.6.7
The Zn2+ (and Cd2+)-ATPase, HMA2. HMA2 maintains metal homeostasis and has a long C-terminal sequence rich in Cys and His residues that binds Zn2+, Kd≈16 nM and regulates activity (Eren et al., 2006).

Accession Number:Q9SZW4
Protein Name:HMA2 aka At4g30110
Length:951
Molecular Weight:101990.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+, Cd2+

Cross database links:

Genevestigator: Q9SZW4
HEGENOM: HBG507745
RefSeq: NP_194740.1   
Entrez Gene ID: 829134   
Pfam: PF00122    PF00702   
KEGG: ath:AT4G30110   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0016463 F:zinc-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASKKMTKSY FDVLGICCTS EVPLIENILN SMDGVKEFSV IVPSRTVIVV HDTLILSQFQ 
61:	IVKALNQAQL EANVRVTGET NFKNKWPSPF AVVSGILLLL SFFKYLYSPF RWLAVAAVVA 
121:	GIYPILAKAV ASLARFRIDI NILVVVTVGA TIGMQDYTEA AVVVFLFTIA EWLQSRASYK 
181:	ASAVMQSLMS LAPQKAVIAE TGEEVEVDEL KTNTVIAVKA GETIPIDGVV VDGNCEVDEK 
241:	TLTGEAFPVP KLKDSTVWAG TINLNGYITV NTTALAEDCV VAKMAKLVEE AQNSKTETQR 
301:	FIDKCSKYYT PAIILISICF VAIPFALKVH NLKHWVHLAL VVLVSACPCG LILSTPVATF 
361:	CALTKAATSG LLIKGADYLE TLAKIKIVAF DKTGTITRGE FIVMDFQSLS EDISLQSLLY 
421:	WVSSTESKSS HPMAAAVVDY ARSVSVEPKP EAVEDYQNFP GEGIYGKIDG KEVYIGNKRI 
481:	ASRAGCLSVP DIDVDTKGGK TIGYVYVGET LAGVFNLSDA CRSGVAQAMK ELKSLGIKIA 
541:	MLTGDNHAAA MHAQEQLGNA MDIVRAELLP EDKSEIIKQL KREEGPTAMV GDGLNDAPAL 
601:	ATADIGISMG VSGSALATET GNIILMSNDI RRIPQAIKLA KRAKRKVVEN VVISITMKGA 
661:	ILALAFAGHP LIWAAVLADV GTCLLVILNS MLLLSDKHKT GNKCYRESSS SSVLIAEKLE 
721:	GDAAGDMEAG LLPKISDKHC KPGCCGTKTQ EKAMKPAKAS SDHSHSGCCE TKQKDNVTVV 
781:	KKSCCAEPVD LGHGHDSGCC GDKSQQPHQH EVQVQQSCHN KPSGLDSGCC GGKSQQPHQH 
841:	ELQQSCHDKP SGLDIGTGPK HEGSSTLVNL EGDAKEELKV LVNGFCSSPA DLAITSLKVK 
901:	SDSHCKSNCS SRERCHHGSN CCRSYAKESC SHDHHHTRAH GVGTLKEIVI E