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3.A.3.6.8
The Cd2+ resistance ATPase, CadA (Wu et al., 2006)

Accession Number:Q60048
Protein Name:Cadmium efflux ATPase
Length:711
Molecular Weight:77089.00
Species:Listeria monocytogenes [1639]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cd2+

Cross database links:

Pfam: PF00122    PF00403    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport
GO:0046686 P:response to cadmium ion

References (2)

[1] “Plasmid-borne cadmium resistance genes in Listeria monocytogenes are similar to cadA and cadC of Staphylococcus aureus and are induced by cadmium.”  Lebrun M.et.al.   8188605
[2] “Plasmid-borne cadmium resistance genes in Listeria monocytogenes are present on Tn5422, a novel transposon closely related to Tn917.”  Lebrun M.et.al.   8188606
Structure:
2AJ0   2AJ1     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEKTVYRVD GLSCTNCAAK FERNVKEIEG VTEAIVNFGA SKITVTGEAS IQQVEQAGAF 
61:	EHLKIIPEKE SFTDPEHFTD HQSFIRKNWR LLLSGLFIAV GYASQIMNGE DFYLTNALFI 
121:	FAIFIGGYSL FKEGFKNLLK FEFTMETLMT IAIIGAAFIG EWAEGSIVVI LFAVSEALER 
181:	YSMDKARQSI RSLMDIAPKE ALVRRSGTDR MVHVDDIQIG DIMIIKPGQK IAMDGHVVKG 
241:	YSAVNQAAIT GESIPVEKNI DDSVFAGTLN EEGLLEVAVT KRVEDTTISK IIHLVEEAQG 
301:	ERAPAQAFVD TFAKYYTPAI IVIAALIATV PPLLFGGNWE TWVYQGLSVL VVGCPCALVV 
361:	STPVAIVTAI GNAAKNGVLV KGGVYLEEIG GLKAIAFDKT GTLTKGVPVV TDYIELTEAT 
421:	NIQHNKNYII MAALEQLSQH PLASAIIKYG ETREMDLTSI NVNDFTSITG KGIRGTVDGN 
481:	TYYVGSPVLF KELLASQFTD SIHRQVSDLQ LKGKTAMLFG TNQKLISIVA VADEVRSSSQ 
541:	HVIKRLHELG IEKTIMLTGD NQATAQAIGQ QVGVSEIEGE LMPQDKLDYI KQLKINFGKV 
601:	AMVGDGINDA PALAAATVGI AMGGAGTDTA IETADVALMG DDLQKLPFTV KLSRKTLQII 
661:	KQNITFSLVI KLIALLLVIP GWLTLWIAIM ADMGATLLVT LNGLRLMKVK D