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3.A.3.6.9
The Zn2+ uptake ATPase, ZosA (YkvW) (Gaballa and Helmann, 2002)

Accession Number:O31688
Protein Name:YkvW aka ZosA
Length:637
Molecular Weight:68566.00
Species:Bacillus subtilis [1423]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_389268.1   
Entrez Gene ID: 939268   
Pfam: PF00122    PF00702   
BioCyc: SUBTI:BSU13850-MONOMER   
KEGG: bsu:BSU13850   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0016463 F:zinc-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006829 P:zinc ion transport

References (2)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[2] “A peroxide-induced zinc uptake system plays an important role in protection against oxidative stress in Bacillus subtilis.”  Gaballa A.et.al.   12180919

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNEQVIVQRD PHEPLKTDKR EKNWAQHAEL IAALVSGALI LAGWLLSGYQ VLSIILFLLA 
61:	FVIGGFAKAK EGIEETLESK TLNVELLMIF AAIGSALIGY WAEGAILIFI FSLSGALETY 
121:	TMNKSSRDLT SLMQLEPEEA TLMVNGETKR VPVSDLQAGD MIVIKPGERV AADGIIESGS 
181:	TSLDESALTG ESMPVEKNTG DTVFTGTVNR NGSLTVRVTK ANEDSLFRKI IKLVESAQNS 
241:	VSPAQAFIER FENAYVKGVL IAVALLLFVP HFALGWSWSE TFYRAMVFMV VASPCALVAS 
301:	IMPAALSLIS NGARNGMLVK GSVFLEQLGS VQMIAFDKTG TVTKGQPAVE TIRIAEGFSE 
361:	AEVLEAVYAI ETQSSHPLAQ AITAYAESRG VNQSGYISIE ETSGFGVMAE VSGAKWKVGK 
421:	AGFIGEEMAA QFMKQTASDV IQSGHTIVFV KKDDQIAGCI ALKDQIRPEA KEVMEELNRL 
481:	GIKTAMLTGD HEDTAQAIAK EAGMTTVVAE CLPDQKVNEI KRLKEEFGTI AMVGDGINDA 
541:	PALKAADVGI AMGGGTDVAL ETADMVLMKN DLKKLVNMCR LSRKMNRIIK QNIVFSLAVI 
601:	CLLICANFLQ AMELPFGVIG HEGSTILVIL NGLRLLK