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3.A.3.8.12
Probable phospholipid-transporting ATPase IF (EC 3.6.3.1) (ATPase IR) (ATPase class VI type 11B)

Accession Number:Q9Y2G3
Protein Name:Probable phospholipid-transporting ATPase IF
Length:1177
Molecular Weight:134190.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Recycling endosome membrane1 / Multi-pass membrane protein2
Substrate phospholipids

Cross database links:

Genevestigator: Q9Y2G3
eggNOG: COG0474
HEGENOM: HOG000202528
Entrez Gene ID: 23200   
Pfam: PF00122    PF00702   
KEGG: hsa:23200   

Gene Ontology

GO:0005769 C:early endosome
GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005637 C:nuclear inner membrane
GO:0005886 C:plasma membrane
GO:0055037 C:recycling endosome
GO:0055038 C:recycling endosome membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0005488 F:binding
GO:0015075 F:ion transmembrane transporter activity
GO:0000287 F:magnesium ion binding
GO:0004012 F:phospholipid-translocating ATPase activity
GO:0015917 P:aminophospholipid transport
GO:0006812 P:cation transport
GO:0045332 P:phospholipid translocation

References (8)

[1] “Differential expression of putative transbilayer amphipath transporters.”  Halleck M.S.et.al.   11015572
[2] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Reanalysis of ATP11B, a Type IV P-type ATPase.”  Halleck M.S.et.al.   11790799
[5] “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10231032
[6] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[7] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[8] “ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.”  Takatsu H.et.al.   21914794

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MWRWIRQQLG FDPPHQSDTR TIYVANRFPQ NGLYTPQKFI DNRIISSKYT VWNFVPKNLF 
61:	EQFRRVANFY FLIIFLVQLM IDTPTSPVTS GLPLFFVITV TAIKQGYEDW LRHNSDNEVN 
121:	GAPVYVVRSG GLVKTRSKNI RVGDIVRIAK DEIFPADLVL LSSDRLDGSC HVTTASLDGE 
181:	TNLKTHVAVP ETALLQTVAN LDTLVAVIEC QQPEADLYRF MGRMIITQQM EEIVRPLGPE 
241:	SLLLRGARLK NTKEIFGVAV YTGMETKMAL NYKSKSQKRS AVEKSMNTFL IIYLVILISE 
301:	AVISTILKYT WQAEEKWDEP WYNQKTEHQR NSSKILRFIS DFLAFLVLYN FIIPISLYVT 
361:	VEMQKFLGSF FIGWDLDLYH EESDQKAQVN TSDLNEELGQ VEYVFTDKTG TLTENEMQFR 
421:	ECSINGMKYQ EINGRLVPEG PTPDSSEGNL SYLSSLSHLN NLSHLTTSSS FRTSPENETE 
481:	LIKEHDLFFK AVSLCHTVQI SNVQTDCTGD GPWQSNLAPS QLEYYASSPD EKALVEAAAR 
541:	IGIVFIGNSE ETMEVKTLGK LERYKLLHIL EFDSDRRRMS VIVQAPSGEK LLFAKGAESS 
601:	ILPKCIGGEI EKTRIHVDEF ALKGLRTLCI AYRKFTSKEY EEIDKRIFEA RTALQQREEK 
661:	LAAVFQFIEK DLILLGATAV EDRLQDKVRE TIEALRMAGI KVWVLTGDKH ETAVSVSLSC 
721:	GHFHRTMNIL ELINQKSDSE CAEQLRQLAR RITEDHVIQH GLVVDGTSLS LALREHEKLF 
781:	MEVCRNCSAV LCCRMAPLQK AKVIRLIKIS PEKPITLAVG DGANDVSMIQ EAHVGIGIMG 
841:	KEGRQAARNS DYAIARFKFL SKLLFVHGHF YYIRIATLVQ YFFYKNVCFI TPQFLYQFYC 
901:	LFSQQTLYDS VYLTLYNICF TSLPILIYSL LEQHVDPHVL QNKPTLYRDI SKNRLLSIKT 
961:	FLYWTILGFS HAFIFFFGSY LLIGKDTSLL GNGQMFGNWT FGTLVFTVMV ITVTVKMALE 
1021:	THFWTWINHL VTWGSIIFYF VFSLFYGGIL WPFLGSQNMY FVFIQLLSSG SAWFAIILMV 
1081:	VTCLFLDIIK KVFDRHLHPT STEKAQLTET NAGIKCLDSM CCFPEGEAAC ASVGRMLERV 
1141:	IGRCSPTHIS RSWSASDPFY TNDRSILTLS TMDSSTC