TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.3.8.15
Phospholipid transporting ATPase, Tat1 of 1139 aas.  Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes in an apoptotic process (Darland-Ransom et al. 2008).  Tat1 regulates lysosome biogenesis and endocytosis as well as yolk uptake in oocytes. It is required at multiple steps of the endolysosomal pathway, at least in part by ensuring proper trafficking of cell-specific effector proteins (Ruaud et al. 2009).

Accession Number:Q9U280
Protein Name:Phospholipid-transporting ATPase tat-1
Length:1139
Molecular Weight:128411.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate phospholipids

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPTEARDNNR HIHLGKVRDP HHQHAQRFCS NRISTCKYNG FSFLPRFLYE QFRRYNNIFF 
61:	LAIALLQQIP DVSPTGRYTT AVPFLIILSV SALKEIFEDV KRRRSDNKVN AFSVEILVDG 
121:	HWIEKQWKDV SVGDFIRIDN DSLFPADLLL LASSEQQGMA YIETSNLDGE TNLKIKQALD 
181:	ITSTMTSPEK LSQFESEITC EPPSRHVNEF NGNIEINGVA RHFGIDQLLL RGARLKNTAW 
241:	IFGAVIYTGH DSKLLMNSKR APLKSGTIDV QTNYRIIFLF FVLVALALIS ATGSEIWRGN 
301:	NIPQAWYLSF LEHDPKGSFL WGVLTFFILY NNLIPISLQV TLEVVRFFQA IYINNDIEMY 
361:	DVNSDSCAIA RTSNLNEELG QVKFIMSDKT GTLTRNVMKF KRLSIGSRNY GNNEDDEFAD 
421:	ASLIEDYRQG DEHSTSILEV LKMMAVCHTV VPENKDGQLI YQSSSPDEAA LVRGAASQSV 
481:	SFHTRQPQKV ICNVFGEDET IEILDVIDFT SDRKRMSVIV RDGAGGDIKL YTKGADTVIF 
541:	ERLEHGKEQE EAVEYCTEHL EDYASFGYRT LCFSMRHLTE QEYSQWAPEY KKAILAIDNR 
601:	AKLLADAAEK LERNMILVGA TAIEDKLQEW VPETIQALMA ADIRVWMLTG DKRETAINIA 
661:	HSCALCHTNT ELLIVDKTTY EETYQKLEQF VARAIELEKQ EKGFAMVIDG KSLLHALTGE 
721:	ARKHFGDLAL RCHAVVCCRM SPMQKAEVVE MVRKLAKHVV LAIGDGANDV AMIQAANVGV 
781:	GISGEEGLQA ASASDYAIPR FHFLRRLLLV HGAWNHDRSV KVILYSFYKN ICLYIIELWF 
841:	AMFSAWSGQT IFERWTIGMF NVIFTAWPPV VLGLFDHPVP AEQIMKYPAL YASFQNRAFS 
901:	IGNFSLWIGL AIVHSLSLFF LTYATMEHQV VWDNGLTGGW LMLGNCAYTF VVATVCFKAL 
961:	LECDSWTWPV VVACIGSIGL WIVFVIVYSL VFPHIGGIGA DMAGMAAIMM SSYTFWLALL 
1021:	FIPLATLLWD LVIKSLFTIA MPTPRELAVM YNKRTTSFNG FERLASYSSN VLENMRLLTS 
1081:	SLRGSTTGST RSRTASEASL ALAEQTRYGF AFSQDESSAV AQTELIRNVD STREKPTGR