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3.A.3.8.19
The Leishmania miltefosine transporter (LMT) is a plasma membrane P4-ATPase that catalyses translocation into the parasite of the leishmanicidal drug, miltefosine as well as phosphatidylcholine and phosphatidylethanolamine analogues. Five highly-conserved amino acids in the cytosolic N-terminal tail (Asn58, Ile60, Lys64, Tyr65 and Phe70) and two (Pro72 and Phe79) in the first TMS were examined, and several of these were important for activity (Perandrés-López et al. 2018). The beta subunit of this system has TC# 8.A.27.1.3.

Accession Number:AHM92900.1
Protein Name:AHM92900.1 miltefosine transporter [Leishmania amazonensis]
Length:1105
Molecular Weight:
Species:Leishmania amazonensis [5659]
Number of TMSs:9
Substrate

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPNQPACWRK CLPTRILPGK LSKSFCCFSA EADVDEDDEV IVYFNNPEAN AQFKYPSNFI 
61:	RTSKYSLISF LPLSLLYEFR KVSNLYFLIN VIFSLIPGVS PLNPATSIAP LSFVLLVAII 
121:	KEAVEDIKRH RADNRANSVL TQVVRKGKLV SVHSKDIHPG DVVRIKNSEE VHADVVMLSS 
181:	SLEEGQAFID TCNLDGESNL KPRRALEVTW GLCKIETIMN TTAVLHTSKP DPGLLSWTGL 
241:	LEINGEEHAL SLDQFLYRGC VLRNTDWAWG MIAYAGVDTK LFRNLKPKPP KSSNLDRKLN 
301:	YFIIAILIFQ NIMLFILASM AVWWNNKYKE TPYLRFFINS RQNITLWGYR YLSYFILLSY 
361:	CVPISLFVTI EVCKVIQAQW MRVDCLMMEY MNNRWRHCQP NTSNLNEQLG MVRFIFSDKT 
421:	GTLTENVMKF KQGDALGIPI EADSLDKCIV QLRKETESKR LGPLQEYFLA LALCNTVQPF 
481:	KDDTDGLSVI YEGSSPDEVA LVETAAAVGY RLINRTTKSI TLLLQNDTRK VYNILATLEF 
541:	TPDRKMMSII VEDSDTKQIM LYNKGADSFI RPQLSRAPDV QEHIESVDIP LTEMSSSGLR 
601:	TLLVCAKDIT RRQFDLWYEK FVEVGKSLHN RSSKIDKVCL EMEQDMRLVG ATAIEDKLQD 
661:	EVPETLSFFL NAGVIIWMLT GDKRETAVTI AATSTLCDPR NDFIDHVDIG HLNPSDPKAI 
721:	ERVGRDLDVV EQHIALKGTH KERRCTLVID GPALNISMEH YFNQFLRISH QLNSAVCCRL 
781:	TPIQKASVVR MFQKSTGKTA LAIGDGANDV SMIREGRVGV GIIGVEGAHA ALAADYAIPR 
841:	FKHLRRLCAV HGRYSLFRNA SCILVSFHKN ITVSVVQFIF AFYVGFSGLT LFDGWMLTFY 
901:	NVLMTSVPPF FMGIFDKDLP EEALLERPKL YTPLSHGEYF NVATLLRWFA ESLITALILF 
961:	YAAYPTLVHQ DGSHQRYTGA ETGTLVFSGL ILVIQTRFAL QIRYWQWLQV FGMVMALSFF 
1021:	LLLFLVYSAI PSIFSDTNFY YQAFDLMSTA KYWFFLLLYV GIELVAVLGF IVFQKSLFPT 
1081:	LRDVAERQHA LQKSGRRRRS LDSA