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3.A.3.8.3
Miltefosine/glycerophospholipid uptake translocase and phospholipid uptake flippase, MIL (Pérez-Victoria et al., 2003)

Accession Number:Q6VXY9
Protein Name:Putative miltefosine transporter aka MIL
Length:1097
Molecular Weight:124113.00
Species:Leishmania donovani [5661]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Glycerophospholipids, Miltefosine, phospholipids

Cross database links:

Pfam: PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0000287 F:magnesium ion binding
GO:0004012 F:phospholipid-translocating ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0015914 P:phospholipid transport

References (1)

[1] “Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.”  Perez-Victoria F.J.et.al.   14514670

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPNQPPCWRK CLSTRIFPDK LSKSFCCFSA EADVDEDDEV IVYLNDPELN AQFNYPSNFI 
61:	RTSKYTLISF LPLSLLLEFK KVSNLYFLMN VIFSLIPGVS PLSPATSIAP LSFVLIVALI 
121:	KEGVEDIKRH QADNRANSIL VQVLRNGKLV SVHSKDIHPG DVMRIKNGEE VRADVVMLAS 
181:	SVEEGQAFID TCNLDGETNL KSRKALEATW ALCEVEAIMN STAVLHTSKP DPGLLSWAGL 
241:	LEINGEEHAL SLNQFLYRGC VLRNTDWVWG MVAYAGVDTK LFRNLKPKPP KSSNLDRKLN 
301:	YFIIAILIFQ NIMLFILASM AVWWNSKYRE TPYLRFFISF RKNVTLWGYR YLSYFILLSY 
361:	CVPISLFITI EVCKVVQAQW MRVDCLMMEY MSNRWRHCQP NTSNLNEQLA MVRFIFSDKT 
421:	GTLTENVMKF KLGDALGNPI DADNLDECIA QLRKEAESKG LGPLQEYFLA LALCNTVQPF 
481:	KDDTDDLGVV YEGSSPDEVA LVETAAAVGY RLISRTTKSI TLLLHDGTRK VYNILATLEF 
541:	TPDRKMMSII VEDSDTKKIT LYNKGADSFI RPQLSRAPDV QGHIENVEIP LTEMSSSGLR 
601:	TLLVCAKDIT RRQFDPWFEK FVEAGKSLHN RSSNIDKVCL EMEQDMRLVG ATAIEDKLQD 
661:	EVPETLSFFL SAGVIIWMLT GDKRETAVTI AATSTLCDPR NDFIDHIDIG HLNSSDPKAI 
721:	ERVGRDLEVV EQHIALKGTH KERRCTLVID GPALNIAMEH YFDQFLRLSH QVNSAVCCRL 
781:	TPIQKATVVR MFQKSTGKTA LAIGDGANDV SMIREGRVGV GIIGLEGAHA ALAADYAIPR 
841:	FKHLRRLCAV HGRYSLFRNA SCILVSFHKN ITVSVVQFIF AFYVGFSGLT LFDGWMLTFY 
901:	NVLLTSIPPF FMGIFDKDLP EDALLERPKL YTPLSHGEYF NLATLLRWFV ESLTTAVILF 
961:	YAAYPTLIRQ DGSHQRYTGG ETGTLVFSGL ILVIQTRFIL QIRYWQWLQV FGMAMSIFLF 
1021:	LLLFLVYSAI PSVFSDTNFY YQAFDLMSTA KYWFFLLLYV GTEVVVVLGV MTFQKNLFPT 
1081:	LRDVAERQYA VQNGGKL