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3.A.3.8.7
The aminophospholipid ATPase1 (ALA1) (mediate chilling tolerance; Gomes et al., 2000).  Promotes antiviral silencing (Guo et al. 2017).

Accession Number:P98204
Protein Name:Phospholipid-transporting ATPase 1
Length:1158
Molecular Weight:130329.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Aminophospholipids

Cross database links:

Genevestigator: P98204
eggNOG: KOG0206
HEGENOM: HBG745019
RefSeq: NP_568146.1   
Entrez Gene ID: 830375   
Pfam: PF00122    PF00702    PF08282   
KEGG: ath:AT5G04930   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0000287 F:magnesium ion binding
GO:0004012 F:phospholipid-translocating ATPase activity
GO:0005515 F:protein binding
GO:0006754 P:ATP biosynthetic process
GO:0015914 P:phospholipid transport

References (3)

[1] “Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases.”  Gomes E.et.al.   11148289
[2] “Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones.”  Sato S.et.al.   9330910
[3] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDPRKSIDKP PHHDPILGVS SRWSVSSKDN KEVTFGDLGS KRIRHGSAGA DSEMLSMSQK 
61:	EIKDEDARLI YINDPDRTNE RFEFTGNSIK TAKYSVFTFL PRNLFEQFHR VAYIYFLVIA 
121:	VLNQLPQLAV FGRGASIMPL AFVLLVSAIK DAYEDFRRHR SDRVENNRLA LVFEDHQFRE 
181:	KKWKHIRVGE VIKVQSNQTL PCDMVLLATS DPTGVVYVQT TNLDGESNLK TRYAKQETLL 
241:	KAADMESFNG FIKCEKPNRN IYGFQANMEI DGRRLSLGPS NIILRGCELK NTAWALGVVV 
301:	YAGGETKAML NNSGAPSKRS RLETRMNLEI ILLSLFLIVL CTIAAATAAV WLRTHRDDLD 
361:	TILFYRRKDY SERPGGKNYK YYGWGWEIFF TFFMAVIVYQ IMIPISLYIS MELVRIGQAY 
421:	FMTNDDQMYD ESSDSSFQCR ALNINEDLGQ IKYLFSDKTG TLTDNKMEFQ CACIEGVDYS 
481:	DREPADSEHP GYSIEVDGII LKPKMRVRVD PVLLQLTKTG KATEEAKRAN EFFLSLAACN 
541:	TIVPIVSNTS DPNVKLVDYQ GESPDEQALV YAAAAYGFLL IERTSGHIVI NVRGETQRFN 
601:	VLGLHEFDSD RKRMSVILGC PDMSVKLFVK GADSSMFGVM DESYGGVIHE TKIQLHAYSS 
661:	DGLRTLVVGM RELNDSEFEQ WHSSFEAAST ALIGRAGLLR KVAGNIETNL RIVGATAIED 
721:	KLQRGVPEAI ESLRIAGIKV WVLTGDKQET AISIGFSSRL LTRNMRQIVI NSNSLDSCRR 
781:	SLEEANASIA SNDESDNVAL IIDGTSLIYV LDNDLEDVLF QVACKCSAIL CCRVAPFQKA 
841:	GIVALVKNRT SDMTLAIGDG ANDVSMIQMA DVGVGISGQE GRQAVMASDF AMGQFRFLVP 
901:	LLLVHGHWNY QRMGYMILYN FYRNAVFVLI LFWYVLFTCY TLTTAITEWS SVLYSVIYTA 
961:	IPTIIIGILD KDLGRQTLLD HPQLYGVGQR AEGYSTTLFW YTMIDTIWQS AAIFFIPMFA 
1021:	YWGSTIDTSS LGDLWTIAAV VVVNLHLAMD VIRWNWITHA AIWGSIVAAC ICVIVIDVIP 
1081:	TLPGYWAIFQ VGKTWMFWFC LLAIVVTSLL PRFAIKFLVE YYRPSDVRIA REAEKLGTFR 
1141:	ESQPVGVEMN LIQDPPRR