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3.A.3.8.9
The phospholipid flipping ATPase (contributes to vesicle biogenesis in the secretory and endocytic pathways). Forms heteromeric complexes with ALIS Cdc50-like β-subunits (ALIS1 = Q9LTW0; TC#8.A.27.1.4) promoting functionality (López-Marqués et al., 2010). The beta-subunit, CDC50A, allows the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2 (Coleman and Molday, 2011). Promotes antiviral silencing (Guo et al. 2017).

Accession Number:P98205
Protein Name:Putative phospholipid-transporting ATPase 2
Length:1107
Molecular Weight:124836.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate phospholipids

Cross database links:

Genevestigator: P98205
eggNOG: KOG0206
HEGENOM: HBG745019
RefSeq: NP_568633.1   
Entrez Gene ID: 834447   
Pfam: PF00122    PF00702   
KEGG: ath:AT5G44240   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0000287 F:magnesium ion binding
GO:0004012 F:phospholipid-translocating ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0015914 P:phospholipid transport

References (3)

[1] “Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones.”  Sato S.et.al.   9330910
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana.”  Jones A.M.E.et.al.   19245862

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKRFVYINDD EASKELCCDN RISNRKYTLW NFLPKNLWEQ FSRFMNQYFL LIACLQLWSL 
61:	ITPVNPASTW GPLIFIFAVS ASKEAWDDYH RYLSDKKANE KEVWIVKQGI KKHIQAQDIQ 
121:	VGNIVWLREN DEVPCDLVLL GTSDPQGVCY VETAALDGET DLKTRVIPSA CVGIDLELLH 
181:	KMKGVIECPV PDKDIRRFDA NMRLFPPFID NDVCSLTIKN TLLQSCYLRN TEWACGVSVY 
241:	TGNQTKLGMS RGIAEPKLTA MDAMIDKLTG AIFVFQIVVV LVLGIAGNVW KDTEARKQWY 
301:	VQYPEEAPWY ELLVIPLRFE LLCSIMIPIS IKVSLDLVKG LYAKFIEWDV EMIDQETGTA 
361:	SYAANTAISE DLGQVEYILT DKTGTLTDNK MIFRRCCIGG IFYGNENGDA LKDAQLLNAI 
421:	TSGSTDVIRF LTVMAICNTV LPVQSKAGDI VYKAQSQDED ALVIAASKLH MVFVGKNANL 
481:	LEIRFNGSVI RYEVLEILEF TSDRKRMSVV VKDCQNGKII LLSKGADEAI LPYARAGQQT 
541:	RTIGDAVEHY SQLGLRTLCL AWRELEENEY LEWSVKFKEA SSLLVDREWR IAEVCQRLEH 
601:	DLYILGVTAI EDRLQDGVPE TIETLRKAGI NFWMLTGDKQ NTAIQIALSC NFISPEPKGQ 
661:	LLMIDGKTEE DVSRSLERVL LTMRITASEP KDVAFVIDGW ALEIALKHHR KDFVELAILS 
721:	RTAICCRVTP SQKAQLVEIL KSCDYRTLAI GDGGNDVRMI QQADIGVGIS GREGLQAARA 
781:	ADYSIGRFRF LKRLILVHGR YSYNRTAFLS QYSFYKSLLI CFIQIFFSFI SGVSGTSLFN 
841:	SVSLMAYNVF YTSVPVLVSV IDKDLSEASV MQHPQILFYC QAGRLLNPST FAGWFGRSLF 
901:	HAIIVFVITI HAYAYEKSEM EELGMVALSG CIWLQAFVVA QETNSFTVLQ HLSIWGNLVG 
961:	FYAINFLFSA IPSSGMYTIM FRLCSQPSYW ITMFLIVGAG MGPIFALKYF RYTYRPSKIN 
1021:	ILQQAERMGG PILTLGNIET QPRTIEKDLS PISITQPKNR SPVYEPLLSD SPNATRRSFG 
1081:	PGTPFEFFQS QSRLSSSSGY TRNCKDN