TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.3.9.1
Na+-ATPase (efflux)

Accession Number:P13587
Protein Name:ATN1 aka Pmr2ap aka ENa1 aka PMR2 aka HOR6 aka YDR040C aka YD6888.02C
Length:1091
Molecular Weight:120357.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

Genevestigator: P13587
eggNOG: fuNOG05186
HEGENOM: HBG456486
DIP: DIP-4493N
RefSeq: NP_010325.1   
Entrez Gene ID: 851610   
Pfam: PF00689    PF00690    PF00122    PF00702   
KEGG: sce:YDR040C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0001950 C:plasma membrane enriched fraction
GO:0005524 F:ATP binding
GO:0008556 F:potassium-transporting ATPase activity
GO:0008554 F:sodium-exporting ATPase activity, phosphory...
GO:0006754 P:ATP biosynthetic process
GO:0042149 P:cellular response to glucose starvation
GO:0006972 P:hyperosmotic response
GO:0006813 P:potassium ion transport
GO:0009268 P:response to pH
GO:0009651 P:response to salt stress
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (11)

[1] “The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family.”  Rudolph H.K.et.al.   2526682
[2] “The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.”  Wieland J.et.al.   7664728
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[4] “A PMR2 tandem repeat with a modified C-terminus is located downstream from the KRS1 gene encoding lysyl-tRNA synthetase in Saccharomyces cerevisiae.”  Martinez R.et.al.   2046655
[5] “The yeast lysyl-tRNA synthetase gene. Evidence for general amino acid control of its expression and domain structure of the encoded protein.”  Mirande M.et.al.   2903861
[6] “Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast.”  Marquez J.A.et.al.   8612770
[7] “Overexpression of the sodium ATPase of Saccharomyces cerevisiae: conditions for phosphorylation from ATP and Pi.”  Benito B.et.al.   9315618
[8] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[9] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[10] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[11] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGEGTTKENN NAEFNAYHTL TAEEAAEFIG TSLTEGLTQD EFVHRLKTVG ENTLGDDTKI 
61:	DYKAMVLHQV CNAMIMVLLI SMIISFAMHD WITGGVISFV IAVNVLIGLV QEYKATKTMN 
121:	SLKNLSSPNA HVIRNGKSET INSKDVVPGD ICLVKVGDTI PADLRLIETK NFDTDESLLT 
181:	GESLPVSKDA NLVFGKEEET SVGDRLNLAF SSSAVVKGRA KGIVIKTALN SEIGKIAKSL 
241:	QGDSGLISRD PSKSWLQNTW ISTKKVTGAF LGTNVGTPLH RKLSKLAVLL FWIAVLFAII 
301:	VMASQKFDVD KRVAIYAICV ALSMIPSSLV VVLTITMSVG AAVMVSRNVI VRKLDSLEAL 
361:	GAVNDICSDK TGTLTQGKML ARQIWIPRFG TITISNSDDP FNPNEGNVSL IPRFSPYEYS 
421:	HNEDGDVGIL QNFKDRLYEK DLPEDIDMDL FQKWLETATL ANIATVFKDD ATDCWKAHGD 
481:	PTEIAIQVFA TKMDLPHNAL TGEKSTNQSN ENDQSSLSQH NEKPGSAQFE HIAEFPFDST 
541:	VKRMSSVYYN NHNETYNIYG KGAFESIISC CSSWYGKDGV KITPLTDCDV ETIRKNVYSL 
601:	SNEGLRVLGF ASKSFTKDQV NDDQLKNITS NRATAESDLV FLGLIGIYDP PRNETAGAVK 
661:	KFHQAGINVH MLTGDFVGTA KAIAQEVGIL PTNLYHYSQE IVDSMVMTGS QFDGLSEEEV 
721:	DDLPVLPLVI ARCSPQTKVR MIEALHRRKK FCTMTGDGVN DSPSLKMANV GIAMGINGSD 
781:	VSKEASDIVL SDDNFASILN AVEEGRRMTD NIQKFVLQLL AENVAQALYL IIGLVFRDEN 
841:	GKSVFPLSPV EVLWIIVVTS CFPAMGLGLE KAAPDLMDRP PHDSEVGIFT WEVIIDTFAY 
901:	GIIMTGSCMA SFTGSLYGIN SGRLGHDCDG TYNSSCRDVY RSRSAAFATM TWCALILAWE 
961:	VVDMRRSFFR MHPDTDSPVK EFFRSIWGNQ FLFWSIIFGF VSAFPVVYIP VINDKVFLHK 
1021:	PIGAEWGLAI AFTIAFWIGA ELYKCGKRRY FKTQRAHNPE NDLESNNKRD PFEAYSTSTT 
1081:	IHTEVNIGIK Q