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4.C.2.1.2
Peroxisomal carnitine O-octanoyl transferase (CrOT)

Accession Number:Q9UKG9
Protein Name:CrOT or COT
Length:612
Molecular Weight:70178.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Peroxisome1
Substrate Carnitine O-octanoyl

Cross database links:

Genevestigator: Q9UKG9
RefSeq: NP_066974.2   
Entrez Gene ID: 54677   
Pfam: PF00755   
Drugbank: Drugbank Link   
OMIM: 606090  gene

Gene Ontology

GO:0005782 C:peroxisomal matrix
GO:0008458 F:carnitine O-octanoyltransferase activity
GO:0006631 P:fatty acid metabolic process
GO:0006091 P:generation of precursor metabolites and energy
GO:0006810 P:transport

References (4)

[1] “Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids.”  Ferdinandusse S.et.al.   10486279
[2] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.”  Morillas M.et.al.   11790793

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENQLAKSTE ERTFQYQDSL PSLPVPSLEE SLKKYLESVK PFANQEEYKK TEEIVQKFQS 
61:	GIGEKLHQKL LERAKGKRNW LEEWWLNVAY LDVRIPSQLN VNFAGPAAHF EHYWPPKEGT 
121:	QLERGSITLW HNLNYWQLLR KEKVPVHKVG NTPLDMNQFR MLFSTCKVPG ITRDSIMNYF 
181:	RTESEGRSPN HIVVLCRGRA FVFDVIHEGC LVTPPELLRQ LTYIHKKCHS EPDGPGIAAL 
241:	TSEERTRWAK AREYLIGLDP ENLALLEKIQ SSLLVYSMED SSPHVTPEDY SEIIAAILIG 
301:	DPTVRWGDKS YNLISFSNGV FGCNCDHAPF DAMIMVNISY YVDEKIFQNE GRWKGSEKVR 
361:	DIPLPEELIF IVDEKVLNDI NQAKAQYLRE ASDLQIAAYA FTSFGKKLTK NKMLHPDTFI 
421:	QLALQLAYYR LHGHPGCCYE TAMTRHFYHG RTETMRSCTV EAVRWCQSMQ DPSVNLRERQ 
481:	QKMLQAFAKH NKMMKDCSAG KGFDRHLLGL LLIAKEEGLP VPELFTDPLF SKSGGGGNFV 
541:	LSTSLVGYLR VQGVVVPMVH NGYGFFYHIR DDRFVVACSA WKSCPETDAE KLVQLTFCAF 
601:	HDMIQLMNST HL