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5.B.6.1.2
Metalloreductase STEAP2 or STAMP1 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer; PUMPCn) Six-transmembrane epithelial antigen of prostate 2) (6TM protein of prostate 1). Membrane cholesterol modulates the STEAP2 conformation during intracellular trafficking, leading to a broad subcellular distribution (Hasegawa et al. 2018).

Accession Number:Q8NFT2
Protein Name:Metalloreductase STEAP2
Length:490
Molecular Weight:56056.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: Q8NFT2
eggNOG: COG2085
HEGENOM: HOG000234491
Entrez Gene ID: 261729   
Pfam: PF03807    PF01794   
KEGG: hsa:261729   

Gene Ontology

GO:0005829 C:cytosol
GO:0005769 C:early endosome
GO:0010008 C:endosome membrane
GO:0030173 C:integral to Golgi membrane
GO:0005886 C:plasma membrane
GO:0030140 C:trans-Golgi network transport vesicle
GO:0042598 C:vesicular fraction
GO:0009055 F:electron carrier activity
GO:0050660 F:flavin adenine dinucleotide binding
GO:0005506 F:iron ion binding
GO:0000166 F:nucleotide binding
GO:0016491 F:oxidoreductase activity
GO:0005215 F:transporter activity
GO:0022900 P:electron transport chain
GO:0006897 P:endocytosis
GO:0006893 P:Golgi to plasma membrane transport
GO:0006811 P:ion transport
GO:0055072 P:iron ion homeostasis
GO:0045055 P:regulated secretory pathway
GO:0009725 P:response to hormone stimulus

References (6)

[1] “Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer.”  Korkmaz K.S.et.al.   12095985
[2] “Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.”  Porkka K.P.et.al.   12429817
[3] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[4] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[5] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[6] “The Steap proteins are metalloreductases.”  Ohgami R.S.et.al.   16609065

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI RCGYHVVIGS 
61:	RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS LWDLRHLLVG KILIDVSNNM 
121:	RINQYPESNA EYLASLFPDS LIVKGFNVVS AWALQLGPKD ASRQVYICSN NIQARQQVIE 
181:	LARQLNFIPI DLGSLSSARE IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA 
241:	RNQQSDFYKI PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ 
301:	CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN EEEVWRIEMY 
361:	ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY VALLISTFHV LIYGWKRAFE 
421:	EEYYRFYTPP NFVLALVLPS IVILGKIILF LPCISRKLKR IKKGWEKSQF LEEGMGGTIP 
481:	HVSPERVTVM