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8.A.1.3.1
MFP cluster 3 (function with ABC porters) (Pimenta et al., 2005)

Accession Number:P06739
Protein Name:HlyD
Length:478
Molecular Weight:54541.00
Species:Escherichia coli [562]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass type II membrane protein2

Cross database links:

DIP: DIP-28121N
Pfam: PF00529   

Gene Ontology

GO:0009276 C:Gram-negative-bacterium-type cell wall
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009306 P:protein secretion

References (1)

[1] “A topological model for the haemolysin translocator protein HlyD.”  Schuelein R.et.al.   1495479

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MKTWLMGFSE FLLRYKLVWS ETWKIRKQLD TPVREKDENE FLPAHLELIE TPVSRRPRLV 
61:	AYFIMGFLVI AFILSVLGQV EIVATANGKL THSGRSKEIK PIENSIVKEI IVKEGESVRK 
121:	GDVLLKLTAL GAEADTLKTQ SSLLQARLEQ TRYQILSRSI ELNKLPELKL PDEPYFQNVS 
181:	EEEVLRLTSL IKEQFSTWQN QKYQKELNLD KKRAERLTVL ARINRYENLS RVEKSRLDDF 
241:	SSLLHKQAIA KHAVLEQENK YVEAVNELRV YKSQLEQIES EILSAKEEYQ LVTQLFKNEI 
301:	LDKLRQTTDN IGLLTLELAK NEERQQASVI RAPVSVKVQQ LKVHTEGGVV TTAETLMVIV 
361:	PEDDTLEVTA LVQNKDIGFI NVGQNAIIKV EAFPYTRYGY LVGKVKNINL DAIEDQRLGL 
421:	VFNVIISIEE NCLSTGNKNI PLSSGMAVTA EIKTGMRSVI SYLLSPLEES VTESLRER