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8.A.102.1.2
Reticulon-3, Rtn3, of 964 aas and 3 - 4 TMSs at the C-terminus of the protein. May be involved in membrane trafficking in the early secretory pathway. Rtn3 inhibits BACE1 activity and amyloid precursor protein processing and may induce the caspase-8 cascade and apoptosis. May also favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress, and induces the formation of endoplasmic reticulum tubules (Yamamoto et al. 2014).

Accession Number:Q9ES97
Protein Name:Reticulon-3
Length:964
Molecular Weight:103879.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAESSAATQS PSVSSSSSGA EPSALGGGGG SPGACPALGA KSCGSSCADS FVSSSSSQPV 
61:	SIFSTSQAGL SSLCSDEPPS KSMTSSFLSS SEIHNPDPTT PLGEKSETLG SQFVLAKGKD 
121:	PLVLLDKKKL DSPQGTNKDR VDAPVSLATG IPCSHPSIPD SFPEQPAFLS KEIGPAEEWV 
181:	VKDQEPKNPN KVPDGEDRSA LDFGQSKAEH ICTYSLSPSE LPVASVEKDS PESPFEVIID 
241:	KATFDREFKD LYKENPNDLG GWAAHGDRES PADLLEMNDK LFPLRNKEAG RYPSSVLLGR 
301:	QFSHTTAALE EVSRCVNDMH NFTNEILTWD LDPQAKQQAN KTSCTTESTG LDRSELRSEI 
361:	PVINLKTNPQ QKMPVCSFNG STPITKSTGD WTEAFTEGKP VRDYLSSTKE AGGNGVPGSS 
421:	QLHSELPGSM PEKWVSGSGA ATVEVTLPNL RGAWPNSVMG EVTEVDSSGE SDDTVIEDIT 
481:	EKPDSLPSAA AKTSEREIKE TPSRETVRSE MCENSEQPQA QPETPTQKSL EGEVASQVPN 
541:	TLNEVTPEKL DMTNNPKVCS AAPPSVLNET GFSLTVPASA KLESLLGKYV EDTDGSSPED 
601:	LMAVLTGAEE KGIVDKEEGD VLEAVLEKIA DFKNTLPVEL LHESELSGSE TKNIKSKYSE 
661:	DSRETTGGAP TMSPDLEQEQ LTIRAIKELG ERQAEKVQDE GISSGGKLKQ TFAPQSGPQS 
721:	SSDILEHTDV KTGSDLGIPK NPTIIKNTRI DSISSLTKTE MVNKNVLARL LSDFPVHDLI 
781:	FWRDVKKTGF VFGTTLIMLL SLAAFSVISV VSYLILALLS VTISFRVYKS VIQAVQKSEE 
841:	GHPFKAYLDV DITLSSEAFH NYMNAAMVHV NKALKLIIRL FLVEDLVDSL KLAVFMWLMT 
901:	YVGAVFNGIT LLILAELLVF SVPIVYEKYK TQIDHYVGIA RDQTKSIVEK IQAKLPGIAK 
961:	KKAE