8.A.102.1.2
Reticulon-3, Rtn3, of 964 aas and 3 - 4 TMSs at the C-terminus of the protein. May be involved in membrane trafficking in
the early secretory pathway. Rtn3 inhibits BACE1 activity and amyloid
precursor protein processing and may induce the caspase-8 cascade and
apoptosis. May also favor BCL2 translocation to the mitochondria upon
endoplasmic reticulum stress, and induces the formation of
endoplasmic reticulum tubules (Yamamoto et al. 2014).
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| Accession Number: | Q9ES97 |
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| Protein Name: | Reticulon-3 |
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| Length: | 964 |
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| Molecular Weight: | 103879.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MAESSAATQS PSVSSSSSGA EPSALGGGGG SPGACPALGA KSCGSSCADS FVSSSSSQPV
61: SIFSTSQAGL SSLCSDEPPS KSMTSSFLSS SEIHNPDPTT PLGEKSETLG SQFVLAKGKD
121: PLVLLDKKKL DSPQGTNKDR VDAPVSLATG IPCSHPSIPD SFPEQPAFLS KEIGPAEEWV
181: VKDQEPKNPN KVPDGEDRSA LDFGQSKAEH ICTYSLSPSE LPVASVEKDS PESPFEVIID
241: KATFDREFKD LYKENPNDLG GWAAHGDRES PADLLEMNDK LFPLRNKEAG RYPSSVLLGR
301: QFSHTTAALE EVSRCVNDMH NFTNEILTWD LDPQAKQQAN KTSCTTESTG LDRSELRSEI
361: PVINLKTNPQ QKMPVCSFNG STPITKSTGD WTEAFTEGKP VRDYLSSTKE AGGNGVPGSS
421: QLHSELPGSM PEKWVSGSGA ATVEVTLPNL RGAWPNSVMG EVTEVDSSGE SDDTVIEDIT
481: EKPDSLPSAA AKTSEREIKE TPSRETVRSE MCENSEQPQA QPETPTQKSL EGEVASQVPN
541: TLNEVTPEKL DMTNNPKVCS AAPPSVLNET GFSLTVPASA KLESLLGKYV EDTDGSSPED
601: LMAVLTGAEE KGIVDKEEGD VLEAVLEKIA DFKNTLPVEL LHESELSGSE TKNIKSKYSE
661: DSRETTGGAP TMSPDLEQEQ LTIRAIKELG ERQAEKVQDE GISSGGKLKQ TFAPQSGPQS
721: SSDILEHTDV KTGSDLGIPK NPTIIKNTRI DSISSLTKTE MVNKNVLARL LSDFPVHDLI
781: FWRDVKKTGF VFGTTLIMLL SLAAFSVISV VSYLILALLS VTISFRVYKS VIQAVQKSEE
841: GHPFKAYLDV DITLSSEAFH NYMNAAMVHV NKALKLIIRL FLVEDLVDSL KLAVFMWLMT
901: YVGAVFNGIT LLILAELLVF SVPIVYEKYK TQIDHYVGIA RDQTKSIVEK IQAKLPGIAK
961: KKAE
