8.A.103.1.2
SCAMP2 of 329 aas and 4 TMSs. Required for vesicle fusion pore formation (Liu et al. 2005). Interacts directly with the serotonin transporter and promotes its localization to the plasma membrane (Müller et al. 2006). It also interacts directly with the dopamine transporter, DAT, to regluate its activity and localization (Fjorback et al. 2011).
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| Accession Number: | O15127 |
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| Protein Name: | Secretory carrier-associated membrane protein 2 |
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| Length: | 329 |
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| Molecular Weight: | 36649.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSAFDTNPFA DPVDVNPFQD PSVTQLTNAP QGGLAEFNPF SETNAATTVP VTQLPGSSQP
61: AVLQPSVEPT QPTPQAVVSA AQAGLLRQQE ELDRKAAELE RKERELQNTV ANLHVRQNNW
121: PPLPSWCPVK PCFYQDFSTE IPADYQRICK MLYYLWMLHS VTLFLNLLAC LAWFSGNSSK
181: GVDFGLSILW FLIFTPCAFL CWYRPIYKAF RSDNSFSFFV FFFVFFCQIG IYIIQLVGIP
241: GLGDSGWIAA LSTLDNHSLA ISVIMMVVAG FFTLCAVLSV FLLQRVHSLY RRTGASFQQA
301: QEEFSQGIFS SRTFHRAASS AAQGAFQGN