8.A.104.1.10
RAC-α ser/thr kinase, Akt1 (PKB, RAC) of 480 aas. AKT1, AKT2 amd ALT3 regulate glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (Kane et al. 2002). The AKT1 isoform has a more specific role in cell motility and proliferation (Enomoto et al. 2005). Acquired AKT-inhibitor resistance is mediated by ATP-binding cassette transporters in endometrial carcinoma (Takagi et al. 2023).