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8.A.121.1.1
TMEM237 (ALS2CR4) has 408 aas with 4 C-terminal TMSs.  It interacts with the human riboflavin transporter, (h)RFVT-3 (TC#2.A.125.1.2). TMEM237 co-localizes with hRFVT-3 and expressing it caused induces RF uptake, while its knockdown leads to a reduction in uptake. Transfecting TMEM237 into HuTu-80 cells also led to a marked enhancement in hRFVT-3 protein stability, and the level of expression of TMEM237 was reduced following treatment with TNF-alpha (a pro- inflammatory cytokine that inhibits intestinal RF uptake), while its expression was significantly upregulated following treatment with butyrate (an inducer of intestinal RF uptake). Thus, TMEM237 is an interactor with intestinal hRFVT-3, and this interaction affects its stability and activity (Sabui et al. 2019).

Accession Number:Q96Q45
Protein Name:Transmembrane protein 237
Length:408
Molecular Weight:45526.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRTDSGARLE EGHLRPPRAL PPVPSQDDIP LSRPKKKKPR TKNTPASASL EGLAQTAGRR 
61:	PSEGNEPSTK ELKEHPEAPV QRRQKKTRLP LELETSSTQK KSSSSSLLRN ENGIDAEPAE 
121:	EAVIQKPRRK TKKTQPAELQ YANELGVEDE DIITDEQTTV EQQSVFTAPT GISQPVGKVF 
181:	VEKSRRFQAA DRSELIKTTE NIDVSMDVKP SWTTRDVALT VHRAFRMIGL FSHGFLAGCA 
241:	VWNIVVIYVL AGDQLSNLSN LLQQYKTLAY PFQSLLYLLL ALSTISAFDR IDFAKISVAI 
301:	RNFLALDPTA LASFLYFTAL ILSLSQQMTS DRIHLYTPSS VNGSLWEAGI EEQILQPWIV 
361:	VNLVVALLVG LSWLFLSYRP GMDLSEELMF SSEVEEYPDK EKEIKASS