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8.A.131.1.7
Transmembrane protease serine 11A, TMPRSS11A, ECRG1, HATL1, HESP, a Type II transmembrane serine proteases of 421 aas and one N-terminal TMS.  It may play a role in cellular senescence. Overexpression inhibits cell growth and induces G1 cell cycle arrest. It is expressed on the surface of airway epithelial cells and has been shown to cleave and activate spike proteins of the severe acute respiratory syndrome (SARS), SARS-2 and the Middle East respiratory syndrome (MERS) coronaviruses (CoVs). The activation cleavage of human TMPRSS11A is mediated by autocatalysis, and activation cleavage occurred before the protein reached the cell surface (Zhang et al. 2020). TMPRSS11a is an age-altered, tissue specific regulator of migration and wound healing (Fernandez et al. 2021).  

Accession Number:Q6ZMR5
Protein Name:Transmembrane protease serine 11A
Length:421
Molecular Weight:47569.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type II membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY YHGSFKILDP 
61:	QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN YIKNQVVRLT PEEDGVKVDV 
121:	IMVFQFPSTE QRAVREKKIQ SILNQKIRNL RALPINASSV QVNAMSSSTG ELTVQASCGK 
181:	RVVPLNVNRI ASGVIAPKAA WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ 
241:	WTVSFGTKIN PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS 
301:	ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI KPGMFCAGYM 
361:	EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD KPGVYTQVTY YRNWIASKTG 
421:	I