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8.A.16.2.6
Voltage dependent Ca2+ channel γ8 subunit, CACNG8 or TARP γ8, of 425 aas and 4 or 5 TMSs, interacts with calcineurin to regulate AMPA receptor phosphorylation and trafficking (Itakura et al. 2014). It regulates the activity of L-type calcium channels that contain CACNA1C as the pore-forming subunit (Shi et al. 2010). It also regulates the gating properties of AMPARs while promoting their targeting to the cell membrane and synapses and modulating their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (Kato et al. 2010). It does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. TARP gamma8 is predominantly expressed in the forebrain and is enriched in the hippocampus, a region associated with temporal lobe epilepsy, and may allow development of refined AMPAR epilepsy therapeutics (Dohrke et al. 2020).  

Accession Number:Q8WXS5
Protein Name:CACNG8
Length:425
Molecular Weight:43481.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

RefSeq: NP_114101.4   
Entrez Gene ID: 59283   
Pfam: PF00822   
OMIM: 606900  gene
KEGG: hsa:59283   

Gene Ontology

GO:0030666 C:endocytic vesicle membrane
GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport

References (2)

[1] “Calcium channel gamma subunits provide insights into the evolution of this gene family.”  Chu P.-J.et.al.   11738816
[2] “A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.”  Burgess D.L.et.al.   11170751

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL ICNTTNLTAG 
61:	GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV CVKINHFPED TDYDHDSAEY 
121:	LLRVVRASSI FPILSAILLL LGGVCVAASR VYKSKRNIIL GAGILFVAAG LSNIIGVIVY 
181:	ISANAGEPGP KRDEEKKNHY SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS 
241:	DLLKAGGGAG GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA 
301:	STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG GGAGAERDRG 
361:	GSSGFLTLHN AFPKEAGGGV TVTVTRPPAP PAPRHPAPSA PAPGTLAKGA AASNTNTLNR 
421:	KTTPV