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8.A.17.1.1
Sodium channel ß1 (β-1, beta-1) subunit.  This subunit can interact with and regulate the activity of the K+ channel, Kv10.1 of the KCNH family (TC# 1.A.1.2.17) as well as of Na+ channels (Kubota et al. 2017). Both beta1 and beta3 subunits regulate channel gating, expression, and pharmacology. Beta1 regulates NaV1.5 by modulating the 4th voltage-sensing domain, DIV-VSD, whereas beta3 alters channel kinetics mainly through the DIII-VSD interaction (Zhu et al. 2017).

Accession Number:P53788
Protein Name:SCN1B
Length:218
Molecular Weight:24706.00
Species:Oryctolagus cuniculus (Rabbit) [9986]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

eggNOG: maNOG19696
RefSeq: NP_001075828.1   
Entrez Gene ID: 100009211   
Pfam: PF00047   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0006814 P:sodium ion transport

References (1)

[1] “Cloning of the cDNA encoding the sodium channel beta 1 subunit from rabbit.”  Belcher S.M.et.al.   8666261

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGRLLAFVVG AALVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT AETFTEWTFR 
61:	QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYQ 
121:	CHVYRLLSFE NYEHNTSVVK KIHLEVVDKA NRDMASIVSE IMMYVLIVVL TIWLVAEMVY 
181:	CYKKIAAATE AAAQENASEY LAITSESKEN CTGVQVAE