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8.A.23.1.1
Extracellular chaperone protein precursor, Basigin (BSG; CD147). Interacts with MCT1, 3 and 4 (TC# 2.A.1.13.1, 7 and 9, respectively) (Ovens et al., 2010; Halestrap 2012).  May play a role in cancer progression (Kendrick et al. 2016).

Accession Number:P35613
Protein Name:Basigin [Precursor] aka EMMPRIN aka 5F7 aka TCSF
Length:385
Molecular Weight:42200.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P35613
eggNOG: prNOG19015
HEGENOM: HBG444778
RefSeq: NP_001719.2    NP_940991.1    NP_940993.1   
Entrez Gene ID: 682   
OMIM: 109480  gene
111380  phenotype
KEGG: hsa:682   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0042470 C:melanosome
GO:0015129 F:lactate transmembrane transporter activity
GO:0005537 F:mannose binding
GO:0005515 F:protein binding
GO:0007166 P:cell surface receptor linked signaling pathway

References (22)

[1] “Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule.”  Kasinrerk W.et.al.   1634773
[2] “The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen.”  Miyauchi T.et.al.   1783610
[3] “The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.”  Biswas C.et.al.   7812975
[4] “Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.”  Guo H.et.al.   9767135
[5] “Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.”  Ochrietor J.D.et.al.   12939332
[6] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[7] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.”  Zhang Z.et.al.   15340161
[10] “Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor.”  Nabeshima K.et.al.   1846736
[11] “Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion.”  Muramatsu T.et.al.   12792908
[12] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.”  Zhang H.et.al.   12754519
[13] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[14] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.”  Chi A.et.al.   17081065
[15] “junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.”  Schreiner A.et.al.   17267690
[16] “Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.”  Molina H.et.al.   17287340
[17] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[18] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[19] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[20] “Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion.”  Yu X.-L.et.al.   18430721
[21] “Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping.”  Luo J.et.al.   19768682
[22] “The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues.”  Spring F.A.et.al.   9130641
Structure:
3B5H   3I84   3I85   3QQN   3QR2   4U0Q     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 
61:	QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 
121:	RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 
181:	DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 
241:	VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 
301:	CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 
361:	GSAPLKSSGQ HQNDKGKNVR QRNSS