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8.A.24.1.2
Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2, SLC9A3R2

Accession Number:Q15599
Protein Name:Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Length:337
Molecular Weight:37414.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Endomembrane system1 / Peripheral membrane protein2

Cross database links:

Genevestigator: Q15599 Q15599
eggNOG: NOG319972 NOG319972
HEGENOM: HOG000089940 HOG000089940
DIP: DIP-29093N DIP-29093N
Entrez Gene ID: 9351   
Pfam: PF09007    PF00595   
KEGG: hsa:9351    hsa:9351   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0012505 C:endomembrane system
GO:0005634 C:nucleus
GO:0008013 F:beta-catenin binding
GO:0019902 F:phosphatase binding
GO:0008022 F:protein C-terminus binding
GO:0005102 F:receptor binding
GO:0006461 P:protein complex assembly
GO:0005737 C:cytoplasm
GO:0005886 C:plasma membrane
GO:0016247 F:channel regulator activity
GO:0048839 P:inner ear development
GO:0014067 P:negative regulation of phosphatidylinositol 3-kinase cascade
GO:0045838 P:positive regulation of membrane potential

References (32)

[1] “The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains.”  Poulat F.et.al.   9054412
[2] “Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.”  Reczek D.et.al.   9314537
[3] “cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.”  Yun C.H.C.et.al.   9096337
[4] “Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.”  Imai K.et.al.   9831664
[5] “A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.”  Hall R.A.et.al.   9671706
[6] “The sequence and analysis of duplication-rich human chromosome 16.”  Martin J.et.al.   15616553
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.”  Zizak M.et.al.   10455146
[9] “Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1.”  Palmada M.et.al.   14623317
[10] “NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.”  Oh Y.-S.et.al.   15143197
[11] “Large-scale characterization of HeLa cell nuclear phosphoproteins.”  Beausoleil S.A.et.al.   15302935
[12] “Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.”  Meder D.et.al.   15642748
[13] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[14] “MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.”  Arnaud C.et.al.   19555689
[15] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[16] “Structural basis for NHERF recognition by ERM proteins.”  Terawaki S.et.al.   16615918
[17] “The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains.”  Poulat F.et.al.   9054412
[18] “Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.”  Reczek D.et.al.   9314537
[19] “cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.”  Yun C.H.C.et.al.   9096337
[20] “Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.”  Imai K.et.al.   9831664
[21] “A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.”  Hall R.A.et.al.   9671706
[22] “The sequence and analysis of duplication-rich human chromosome 16.”  Martin J.et.al.   15616553
[23] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[24] “cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.”  Zizak M.et.al.   10455146
[25] “Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1.”  Palmada M.et.al.   14623317
[26] “NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.”  Oh Y.-S.et.al.   15143197
[27] “Large-scale characterization of HeLa cell nuclear phosphoproteins.”  Beausoleil S.A.et.al.   15302935
[28] “Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.”  Meder D.et.al.   15642748
[29] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[30] “MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.”  Arnaud C.et.al.   19555689
[31] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[32] “Structural basis for NHERF recognition by ERM proteins.”  Terawaki S.et.al.   16615918

External Searches:

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FASTA formatted sequence
1:	MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN 
61:	GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ LTCTEEMAQR GLPPAHDPWE 
121:	PKPDWAHTGS HSSEAGKKDV SGPLRELRPR LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD 
181:	PGSPAARSGL RAQDRLIEVN GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR 
241:	VTPTEEHVEG PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL 
301:	HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF