| |
|---|---|
| Accession Number: | Q15599 |
| Protein Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| Length: | 337 |
| Molecular Weight: | 37414.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Endomembrane system1 / Peripheral membrane protein2 |
Cross database links:
| Genevestigator: | Q15599 Q15599 |
|---|---|
| eggNOG: | NOG319972 NOG319972 |
| HEGENOM: | HOG000089940 HOG000089940 |
| DIP: | DIP-29093N DIP-29093N |
| Entrez Gene ID: | 9351 |
| Pfam: | PF09007 PF00595 |
| KEGG: | hsa:9351 hsa:9351 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0012505
C:endomembrane system
GO:0005634
C:nucleus
GO:0008013
F:beta-catenin binding
GO:0019902
F:phosphatase binding
GO:0008022
F:protein C-terminus binding
GO:0005102
F:receptor binding
GO:0006461
P:protein complex assembly
GO:0005737
C:cytoplasm
GO:0005886
C:plasma membrane
GO:0016247
F:channel regulator activity
GO:0048839
P:inner ear development
GO:0014067
P:negative regulation of phosphatidylinositol 3-kinase cascade
GO:0045838
P:positive regulation of membrane potential
| |
References (32)[1] “The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains.” Poulat F.et.al. 9054412 [2] “Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.” Reczek D.et.al. 9314537 [3] “cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.” Yun C.H.C.et.al. 9096337 [4] “Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.” Imai K.et.al. 9831664 [5] “A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.” Hall R.A.et.al. 9671706 [6] “The sequence and analysis of duplication-rich human chromosome 16.” Martin J.et.al. 15616553 [7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [8] “cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.” Zizak M.et.al. 10455146 [9] “Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1.” Palmada M.et.al. 14623317 [10] “NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.” Oh Y.-S.et.al. 15143197 [11] “Large-scale characterization of HeLa cell nuclear phosphoproteins.” Beausoleil S.A.et.al. 15302935 [12] “Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.” Meder D.et.al. 15642748 [13] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [14] “MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.” Arnaud C.et.al. 19555689 [15] “Initial characterization of the human central proteome.” Burkard T.R.et.al. 21269460 [16] “Structural basis for NHERF recognition by ERM proteins.” Terawaki S.et.al. 16615918 [17] “The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains.” Poulat F.et.al. 9054412 [18] “Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.” Reczek D.et.al. 9314537 [19] “cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.” Yun C.H.C.et.al. 9096337 [20] “Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.” Imai K.et.al. 9831664 [21] “A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.” Hall R.A.et.al. 9671706 [22] “The sequence and analysis of duplication-rich human chromosome 16.” Martin J.et.al. 15616553 [23] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [24] “cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.” Zizak M.et.al. 10455146 [25] “Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1.” Palmada M.et.al. 14623317 [26] “NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.” Oh Y.-S.et.al. 15143197 [27] “Large-scale characterization of HeLa cell nuclear phosphoproteins.” Beausoleil S.A.et.al. 15302935 [28] “Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.” Meder D.et.al. 15642748 | |
External Searches:
|
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | |||
| FASTA formatted sequence |
|
||
1: MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN 61: GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ LTCTEEMAQR GLPPAHDPWE 121: PKPDWAHTGS HSSEAGKKDV SGPLRELRPR LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD 181: PGSPAARSGL RAQDRLIEVN GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR 241: VTPTEEHVEG PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL 301: HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF
