| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.25.1.1 | Ezrin of 586 aas and 0 TMSs. It is probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, it is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, it is required for normal macropinocytosis. A head-to-tail association, of the N-terminal and C-terminal halves, results in a closed conformation (inactive form) which is incapable of actin or membrane-binding (Matsui et al. 1998). | Eukaryota |
Metazoa, Chordata | Ezrin of Mus musculus (P26040) |
|
8.A.25.1.2 | The 4.1R (Band 4.1) protein of 864 aas. Interacts with many membrane transporters, adhesins and receptors as well as cytoskelectal proteins to help organize the cell envelope (Baines et al. 2014). For example, it interacts with the PMCA1b ATPase (TC# 3.A.3.2.25) (Diaz de Barboza et al. 2015). It affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid (Li et al. 2021). This protein forms a complex with TMEM24 (TC# 8.A.78.1.1) and C2CD2 (TC# 8.A.78.1.2) (Johnson et al. 2024). | Eukaryota |
Metazoa, Chordata | The 4.1R protein of Homo sapiens |
|
8.A.25.1.3 | Merlin, Mer, EMR2, of 635 aas and 1 TMS. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway (Yu et al. 2010). Merlin and Expanded (Q07436; 1,427 aas) function synergistically to control proliferation by regulating the abundance, localization, and turnover of cell-surface receptors (Maitra et al. 2006).
| Eukaryota |
Metazoa, Arthropoda | Merlin of Drosophila melanogaster (Fruit fly) |
|
8.A.25.1.4 | Moesin, Moe, EMR1 of 578 aas and 1 TMS. Moesin is involved in connections of major cytoskeletal structures to the plasma membrane (McCartney and Fehon 1996). It plays a role in nuclear mRNA export together with the mRNA export factor PCID2 (Q9VTL1; 395 aas) and other messenger ribonucleoprotein (mRNP) particles (Kristó et al. 2017). | Eukaryota |
Metazoa, Arthropoda | Moesin of Drosophila melanogaster (Fruit fly) |
|
8.A.25.1.5 | FERM domain-containing protein 7, FERMD7, of 714 aas and 0 TMSs. It plays a role in neurite development, maybe through the activation of the GTPase RAC1, and it may also function in the control of eye movement and gaze stability. FRMD7 mutations disrupt the interaction with GABRA2 and may result in the Infantile Nystagmus Syndrome (Jiang et al. 2020).
| Eukaryota |
Metazoa, Chordata | FERMD7 of Homo sapiens |
|
8.A.25.1.6 | Talin-1, TL-1, of 2541 aas with 1 N-terminal TMS possibly + one or two more later in the protein. | Eukaryota |
Metazoa, Chordata | Talin-1 of Homo sapiens |
|
8.A.25.1.7 | Talin-2, TLN2, of 2542 aas and one N-terminal TMS, possibly with more TMSs in the rest of the protein. As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, it may play a role in cell adhesion. It recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity. | Eukaryota |
Metazoa, Chordata | Talin-2 of Homo sapiens |
|
8.A.25.1.8 | Fermitin-1, Fermt1 (or Kindlerin or Kindlin (KIND or URP1), of 677 aas with one N-terminal TMS + two possible TMSs within the first 120 aas, and another possible TMS at the C-terminus. It is involved in cell adhesion and contributes to integrin activation. When coexpressed with talin (see 8.A.25.1.6/7), it potentiates activation of ITGA2B and is required for normal keratinocyte proliferation. It is required for normal polarization of basal keratinocytes in skin and for normal cell shape. It is required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. It may also mediate TGF-beta 1 signaling in tumor progression (Kloeker et al. 2004). Talin and kindlin cooperate to control the density of integrin clusters (Pernier et al. 2023). | Eukaryota |
Metazoa, Chordata | Fermitin-1 of Homo sapiens |