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| Accession Number: | Q01484 |
| Protein Name: | Ankyrin-B aka ANK2 |
| Length: | 3924 |
| Molecular Weight: | 430255.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | |
Cross database links:
| RefSeq: | NP_001120965.1 NP_001139.3 NP_066187.2 |
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| Entrez Gene ID: | 287 |
| Pfam: | PF00023 PF00531 PF00791 |
| OMIM: |
106410 gene 600919 phenotype |
| KEGG: | hsa:287 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0016323
C:basolateral plasma membrane
GO:0005856
C:cytoskeleton
GO:0031430
C:M band
GO:0005515
F:protein binding
GO:0007165
P:signal transduction
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References (15)[1] “Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes.” Otto E.et.al. 1830053 [2] “440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons.” Chan W.et.al. 8253844 [3] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Isolation and chromosomal localization of a novel nonerythroid ankyrin gene.” Tse W.T.et.al. 1833308 [7] “Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.” Mohler P.J.et.al. 12571597 [8] “Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.” Mohler P.J.et.al. 15262991 [9] “The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.” Lopez C.et.al. 15611082 [10] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [11] “Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.” Molina H.et.al. 17287340 [12] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [13] “Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors.” Kizhatil K.et.al. 19007774 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC 61: NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG 121: ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA 181: ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA 241: AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL 301: TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD 361: VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR IKVMELLVKY 421: GASIQAITES GLTPIHVAAF MGHLNIVLLL LQNGASPDVT NIRGETALHM AARAGQVEVV 481: RCLLRNGALV DARAREEQTP LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE 541: GQVDVASVLL EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL 601: HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN YGAETNIVTK 661: QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH LAAQEDKVNV ADILTKHGAD 721: QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ GANVNAKTKN GYTPLHQAAQ QGHTHIINVL 781: LQHGAKPNAT TANGNTALAI AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT 841: EVLDVSDEEG DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR 901: SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG TENLDNVALS 961: SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA PTRVTCRLVK RHRLATMPPM 1021: VEGEGLASRL IEVGPSGAQF LGPVIVEIPH FAALRGKERE LVVLRSENGD SWKEHFCDYT 1081: EDELNEILNG MDEVLDSPED LEKKRICRII TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS 1141: TVVPQVQAVF PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE PRRRKFHKPI 1201: TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW EDITGTTPLT FVNECVSFTT 1261: NVSARFWLID CRQIQESVTF ASQVYREIIC VPYMAKFVVF AKSHDPIEAR LRCFCMTDDK 1321: VDKTLEQQEN FAEVARSRDV EVLEGKPIYV DCFGNLVPLT KSGQHHIFSF FAFKENRLPL 1381: FVKVRDTTQE PCGRLSFMKE PKSTRGLVHQ AICNLNITLP IYTKESESDQ EQEEEIDMTS 1441: EKNDETESTE TSVLKSHLVN EVPVLASPDL LSEVSEMKQD LIKMTAILTT DVSDKAGSIK 1501: VKELVKAAEE EPGEPFEIVE RVKEDLEKVN EILRSGTCTR DESSVQSSRS ERGLVEEEWV 1561: IVSDEEIEEA RQKAPLEITE YPCVEVRIDK EIKGKVEKDS TGLVNYLTDD LNTCVPLPKE 1621: QLQTVQDKAG KKCEALAVGR SSEKEGKDIP PDETQSTQKQ HKPSLGIKKP VRRKLKEKQK 1681: QKEEGLQASA EKAELKKGSS EESLGEDPGL APEPLPTVKA TSPLIEETPI GSIKDKVKAL 1741: QKRVEDEQKG RSKLPIRVKG KEDVPKKTTH RPHPAASPSL KSERHAPGSP SPKTERHSTL 1801: SSSAKTERHP PVSPSSKTEK HSPVSPSAKT ERHSPASSSS KTEKHSPVSP STKTERHSPV 1861: SSTKTERHPP VSPSGKTDKR PPVSPSGRTE KHPPVSPGRT EKRLPVSPSG RTDKHQPVST 1921: AGKTEKHLPV SPSGKTEKQP PVSPTSKTER IEETMSVREL MKAFQSGQDP SKHKTGLFEH 1981: KSAKQKQPQE KGKVRVEKEK GPILTQREAQ KTENQTIKRG QRLPVTGTAE SKRGVRVSSI 2041: GVKKEDAAGG KEKVLSHKIP EPVQSVPEEE SHRESEVPKE KMADEQGDMD LQISPDRKTS 2101: TDFSEVIKQE LEDNDKYQQF RLSEETEKAQ LHLDQVLTSP FNTTFPLDYM KDEFLPALSL 2161: QSGALDGSSE SLKNEGVAGS PCGSLMEGTP QISSEESYKH EGLAETPETS PESLSFSPKK 2221: SEEQTGETKE STKTETTTEI RSEKEHPTTK DITGGSEERG ATVTEDSETS TESFQKEATL 2281: GSPKDTSPKR QDDCTGSCSV ALAKETPTGL TEEAACDEGQ RTFGSSAHKT QTDSEVQEST 2341: ATSDETKALP LPEASVKTDT GTESKPQGVI RSPQGLELAL PSRDSEVLSA VADDSLAVSH 2401: KDSLEASPVL EDNSSHKTPD SLEPSPLKES PCRDSLESSP VEPKMKAGIF PSHFPLPAAV 2461: AKTELLTEVA SVRSRLLRDP DGSAEDDSLE QTSLMESSGK SPLSPDTPSS EEVSYEVTPK 2521: TTDVSTPKPA VIHECAEEDD SENGEKKRFT PEEEMFKMVT KIKMFDELEQ EAKQKRDYKK 2581: EPKQEESSSS SDPDADCSVD VDEPKHTGSG EDESGVPVLV TSESRKVSSS SESEPELAQL 2641: KKGADSGLLP EPVIRVQPPS PLPSSMDSNS SPEEVQFQPV VSKQYTFKMN EDTQEEPGKS 2701: EEEKDSESHL AEDRHAVSTE AEDRSYDKLN RDTDQPKICD GHGCEAMSPS SSAAPVSSGL 2761: QSPTGDDVDE QPVIYKESLA LQGTHEKDTE GEELDVSRAE SPQADCPSES FSSSSSLPHC 2821: LVSEGKELDE DISATSSIQK TEVTKTDETF ENLPKDCPSQ DSSITTQTDR FSMDVPVSDL 2881: AENDEIYDPQ ITSPYENVPS QSFFSSEESK TQTDANHTTS FHSSEVYSVT ITSPVEDVVV 2941: ASSSSGTVLS KESNFEGQDI KMESQQESTL WEMQSDSVSS SFEPTMSATT TVVGEQISKV 3001: IITKTDVDSD SWSEIREDDE AFEARVKEEE QKIFGLMVDR QSQGTTPDTT PARTPTEEGT 3061: PTSEQNPFLF QEGKLFEMTR SGAIDMTKRS YADESFHFFQ IGQESREETL SEDVKEGATG 3121: ADPLPLETSA ESLALSESKE TVDDEADLLP DDVSEEVEEI PASDAQLNSQ MGISASTETP 3181: TKEAVSVGTK DLPTVQTGDI PPLSGVKQIS CPDSSEPAVQ VQLDFSTLTR SVYSDRGDDS 3241: PDSSPEEQKS VIEIPTAPME NVPFTESKSK IPVRTMPTST PAPPSAEYES SVSEDFLSSV 3301: DEENKADEAK PKSKLPVKVP LQRVEQQLSD LDTSVQKTVA PQGQDMASIA PDNRSKSESD 3361: ASSLDSKTKC PVKTRSYTET ETESRERAEE LELESEEGAT RPKILTSRLP VKSRSTTSSC 3421: RGGTSPTKES KEHFFDLYRN SIEFFEEISD EASKLVDRLT QSEREQEIVS DDESSSALEV 3481: SVIENLPPVE TEHSVPEDIF DTRPIWDESI ETLIERIPDE NGHDHAEDPQ DEQERIEERL 3541: AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER DGKHATDTNL 3601: VECLTKINRM DIVHLMETNT EPLQERISHS YAEIEQTITL DHSEGFSVLQ EELCTAQHKQ 3661: KEEQAVSKES ETCDHPPIVS EEDISVGYST FQDGVPKTEG DSSATALFPQ THKEQVQQDF 3721: SGKMQDLPEE SSLEYQQEYF VTTPGTETSE TQKAMIVPSS PSKTPEEVST PAEEEKLYLQ 3781: TPTSSERGGS PIIQEPEEPS EHREESSPRK TSLVIVESAD NQPETCERLD EDAAFEKGDD 3841: MPEIPPETVT EEEYIDEHGH TVVKKVTRKI IRRYVSSEGT EKEEIMVQGM PQEPVNIEEG 3901: DGYSKVIKRV VLKSDTEQSE DNNE