8.A.31.1.3
The secreted Ly-6/uPAR-related protein, SLURP-1 of 103 aas and 1 or 2 TMSs. It is found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease, Mal de Meleda. SLURP-1 is considered an autocrine/paracrine hormone that regulates growth and differentiation of keratinocytes and controls inflammation and malignant cell transformation. The antiproliferative activity of SLURP-1 is related to the 'metabotropic' signaling pathway through α7-nAChR, that activates intracellular signaling cascades without opening the receptor channel (Lyukmanova et al. 2016). Thus, SLURP-1 is an allosteric antogonist of the α7 nicotinic acetylcholine receptor.