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8.A.40.1.23
Tetraspannin, Tspan18 of 248 aas and 4 TMSs in a 3 + 1 arrangement.  It is a regulator of Orai1, a store-operated Ca2+ channels in the plasma membrane which is critical to cell function. Orai1 loss causes severe immunodeficiency and developmental defects (Noy et al. 2018).

Accession Number:Q96SJ8
Protein Name:Tetraspanin-18
Length:248
Molecular Weight:27710.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGDCLSCMK YLMFVFNFFI FLGGACLLAI GIWVMVDPTG FREIVAANPL LLTGAYILLA 
61:	MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS AAILAFIFRE NLTREFFTKE 
121:	LTKHYQGNND TDVFSATWNS VMITFGCCGV NGPEDFKFAS VFRLLTLDSE EVPEACCRRE 
181:	PQSRDGVLLS REECLLGRSL FLNKQGCYTV ILNTFETYVY LAGALAIGVL AIELFAMIFA 
241:	MCLFRGIQ