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8.A.40.7.2
Uroplakin 1b, UPK1B of 260 aas and 4 TMSs in a 3 + 1 arrangement.  Like UPK1A, it may be a component of the asymmetric unit membrane (AUM), a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells (Chicote et al. 2017). Proper formation of helical bundles consisting of the 4 tetraspanin TMSs seems to be a prerequisite for UPIb to exit from the ER into the plasma membrane (Tu et al. 2006).

Accession Number:O75841
Protein Name:Uroplakin-1b
Length:260
Molecular Weight:29643.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW 
61:	IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA FEVASCITAA TQQDFFTPNL 
121:	FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDNCC GVNGPSDWQK YTSAFRTENN 
181:	DADYPWPRQC CVMNNLKEPL NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI 
241:	LCWTFWVLLG TMFYWSRIEY