8.A.43.1.10
Amphoterin-induced protein 1, AMIGO-1, of 493 aas and 1 TMS. May be involved in fasciculation as well as
myelination of developing neural axons, and may also have a role in regeneration
as well as neural plasticity in the adult nervous system. It is assembled with KCNB1 to modulate the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. In mammalian brain neurons, AMIGO-1 is associated with Kv2 alpha subunits, and Kv2 alpha subunits are obligatory in determining the correct pattern of AMIGO-1 expression, plasma membrane trafficking and clustering (Bishop et al. 2018).
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| Accession Number: | Q86WK6 |
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| Protein Name: | Amphoterin-induced protein 1 |
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| Length: | 493 |
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| Molecular Weight: | 55239.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ QLPNVPHSLP
61: SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF ISSEAFSPVP NLRYLDLSSN
121: QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD RCAFDDMAQL QKLYLSQNQI SRFPLELVKE
181: GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ
241: LSSVMDFQED LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV
301: WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE TLSVELKVHN
361: FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS
421: TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE
481: SVSSVFSDTP IVV