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8.A.43.1.10
Amphoterin-induced protein 1, AMIGO-1, of 493 aas and 1 TMS.  May be involved in fasciculation as well as myelination of developing neural axons, and may also have a role in regeneration as well as neural plasticity in the adult nervous system. It is assembled with KCNB1 to modulate the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. In mammalian brain neurons, AMIGO-1 is associated with Kv2 alpha subunits, and Kv2 alpha subunits are obligatory in determining the correct pattern of AMIGO-1 expression, plasma membrane trafficking and clustering (Bishop et al. 2018).  

Accession Number:Q86WK6
Protein Name:Amphoterin-induced protein 1
Length:493
Molecular Weight:55239.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ QLPNVPHSLP 
61:	SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF ISSEAFSPVP NLRYLDLSSN 
121:	QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD RCAFDDMAQL QKLYLSQNQI SRFPLELVKE 
181:	GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ 
241:	LSSVMDFQED LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV 
301:	WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE TLSVELKVHN 
361:	FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS 
421:	TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE 
481:	SVSSVFSDTP IVV