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8.A.43.1.16
Toll-like receptor 2, TLR2 or TIL4,Lancioni et al. 2011 of 784 aas and 2 TMSs, N- and C-termnal.  It cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (Jin et al. 2007; Lancioni et al. 2011). It forms activation clusters composed of several receptors depending on the ligand. These clusters trigger signaling from the cell surface, and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. It also forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (Triantafilou et al. 2006). It is required for normal uptake of M. tuberculosis, a process that is inhibited by M. tuberculosis LppM. Receptor heterodimerization and co-receptor engagement in TLR2 activation is induced by MIC1 and MIC4 from Toxoplasma gondii (Costa Mendonça-Natividade et al. 2019).  

Accession Number:O60603
Protein Name:Toll-like receptor 2
Length:784
Molecular Weight:89838.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
1FYW   1FYX   1O77   2Z7X   2Z80   6NIG     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL TEAVKSLDLS 
61:	NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 
121:	KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 
181:	IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS 
241:	ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 
301:	DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 
361:	SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNIDI 
421:	SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 
481:	ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 
541:	FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 
601:	LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 
661:	QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 
721:	HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA 
781:	AIKS