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8.A.43.1.17
CD14 of 375 aas and 2 TMSs, N- and C-terminal.  In concert with LBP, it binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (Kelley et al. 2013). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (Haziot et al. 1996). It also acts as a coreceptor for the TLR2:TLR6 heterodimer in response to diacylated lipopeptides, and for the TLR2:TLR1 heterodimer in response to triacylated lipopeptides; these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (Triantafilou et al. 2006). It binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (Estruch et al. 2013).

Accession Number:P08571
Protein Name:Monocyte differentiation antigen CD14
Length:375
Molecular Weight:40076.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate

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Structure:
4GLP     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERASCLLLL LLPLVHVSAT TPEPCELDDE DFRCVCNFSE PQPDWSEAFQ CVSAVEVEIH 
61:	AGGLNLEPFL KRVDADADPR QYADTVKALR VRRLTVGAAQ VPAQLLVGAL RVLAYSRLKE 
121:	LTLEDLKITG TMPPLPLEAT GLALSSLRLR NVSWATGRSW LAELQQWLKP GLKVLSIAQA 
181:	HSPAFSCEQV RAFPALTSLD LSDNPGLGER GLMAALCPHK FPAIQNLALR NTGMETPTGV 
241:	CAALAAAGVQ PHSLDLSHNS LRATVNPSAP RCMWSSALNS LNLSFAGLEQ VPKGLPAKLR 
301:	VLDLSCNRLN RAPQPDELPE VDNLTLDGNP FLVPGTALPH EGSMNSGVVP ACARSTLSVG 
361:	VSGTLVLLQG ARGFA