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8.A.44.1.1
The mitochondrial EF hand Ca2+ uptake porter (MCU; TC# 1.A.77) regulator (MICU1; 476 aas) (also called Ca2+-binding atopy-related autoantigen CALC, or AraCALC) (Perocchi et al., 2010). It is homologous to the bifunctional glutamine amidotransferase/anthranylate phosphoribosyl transferase (PRK14607).  It contributes to metabolism-insulin secretion coupling in clonal pancreatic beta-cells (Alam et al. 2012). MCU forms a complex with MICU1, MICU2 and EMRE in animals (Yuan et al. 2020). Human duchenne muscular dystrophy is associated with the inhibition of calcium uniport in mitochondria and an increased sensitivity of the organelles to the calcium-induced permeability transition (Dubinin et al. 2020). Cardiac mitochondria exhibit higher calcium retention capacity and higher rates of calcium uptake during sleep periods. This is associated with higher expression of clock gene Bmal1, lower expression of per2, greater expression of MICU1 gene (mitochondrial calcium uptake 1), and lower expression of the mitochondrial transition pore regulator gene cyclophilin D. Protein levels of mitochondrial calcium uniporter (MCU), MICU2, and sodium/calcium exchanger (NCLX) were also higher at sleep onset relative to wake periods. While complex I and II-dependent oxygen utilization and the transmembrane potential of cardiac mitochondria were lower during sleep, ROS production was increased, presumably due to mitochondrial calcium sequestration. Thus, retaining mitochondrial calcium in the heart during sleep dissipates the membrane potential, slows respiratory activities, and increases ROS levels, which may contribute to increased vulnerability to cardiac stress during the sleep-wake transition. This pronounced daily oscillations in mitochondrial functions pertaining to stress vulnerability may at least in part explain diurnal prevalence of cardiac pathologies.

Accession Number:Q9BPX6
Protein Name:Calcium uptake protein 1, mitochondrial
Length:476
Molecular Weight:54351.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Single-pass membrane protein2
Substrate NONE

Cross database links:

Entrez Gene ID: 10367   
KEGG: hsa:10367    hsa:10367   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005509 F:calcium ion binding
GO:0070509 P:calcium ion import
GO:0006952 P:defense response
GO:0051561 P:elevation of mitochondrial calcium ion concentration

References (14)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[3] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.”  Natter S.et.al.   9806765
[6] “Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity.”  Aichberger K.J.et.al.   16002733
[7] “MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.”  Perocchi F.et.al.   20693986
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[10] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.”  Natter S.et.al.   9806765
[13] “Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity.”  Aichberger K.J.et.al.   16002733
[14] “MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.”  Perocchi F.et.al.   20693986
Structure:
4NSC   4NSD   6K7Y   6LB7   6LB8   6LE5   6WDN   6WDO   6XJV   6XJX   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL LWKRAHAESP 
61:	PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK KKRSGFRDRK VMEYENRIRA 
121:	YSTPDKIFRY FATLKVISEP GEAEVFMTPE DFVRSITPNE KQPEHLGLDQ YIIKRFDGKK 
181:	ISQEREKFAD EGSIFYTLGE CGLISFSDYI FLTTVLSTPQ RNFEIAFKMF DLNGDGEVDM 
241:	EEFEQVQSII RSQTSMGMRH RDRPTTGNTL KSGLCSALTT YFFGADLKGK LTIKNFLEFQ 
301:	RKLQHDVLKL EFERHDPVDG RITERQFGGM LLAYSGVQSK KLTAMQRQLK KHFKEGKGLT 
361:	FQEVENFFTF LKNINDVDTA LSFYHMAGAS LDKVTMQQVA RTVAKVELSD HVCDVVFALF 
421:	DCDGNGELSN KEFVSIMKQR LMRGLEKPKD MGFTRLMQAM WKCAQETAWD FALPKQ