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8.A.49.1.1
The Klotho (KL; α-Klotho; alpha-Klotho) protein of 1012 aas and 2 (or more) TMSs, N- and C-terminal.  Activates several transporters including the creatine transporter, CreaT or SLC6A8 (TC# 2.A.22.3.11; Almilaji et al. 2014) and the TRP6 cation channel (Smith et al. 2017).  Klotho also regulates diverse calcium and potassium ion channels as well as several carriers including the Na+-coupled excitatory amino acid transporters EAAT3 and EAAT4, the Na+-coupled phosphate cotransporters, NaPi-IIa and NaPi-IIb, and a Na+/K+-ATPase. All these cellular transport regulations contribute in the aging suppressor role of Klotho (Sopjani et al. 2014). α-Klotho is associated with phosphate, vitamin D, and calcium homeostasis. The calcium imbalance in α-Klotho-negative mice may induce calpain overactivation, leading to cell death and tissue destruction. α-Klotho has glycosidase activity, capable of modifying the N-glycans of channels and transporters and regulating transmembrane movement of several ions, including calcium (Akasaka-Manya et al. 2016). It regulates diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles (Xie et al. 2020).

Accession Number:Q9UEF7
Protein Name:Klotho
Length:1012
Molecular Weight:116181.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPASAPPRRP RPPPPSLSLL LVLLGLGGRR LRAEPGDGAQ TWARFSRPPA PEAAGLFQGT 
61:	FPDGFLWAVG SAAYQTEGGW QQHGKGASIW DTFTHHPLAP PGDSRNASLP LGAPSPLQPA 
121:	TGDVASDSYN NVFRDTEALR ELGVTHYRFS ISWARVLPNG SAGVPNREGL RYYRRLLERL 
181:	RELGVQPVVT LYHWDLPQRL QDAYGGWANR ALADHFRDYA ELCFRHFGGQ VKYWITIDNP 
241:	YVVAWHGYAT GRLAPGIRGS PRLGYLVAHN LLLAHAKVWH LYNTSFRPTQ GGQVSIALSS 
301:	HWINPRRMTD HSIKECQKSL DFVLGWFAKP VFIDGDYPES MKNNLSSILP DFTESEKKFI 
361:	KGTADFFALC FGPTLSFQLL DPHMKFRQLE SPNLRQLLSW IDLEFNHPQI FIVENGWFVS 
421:	GTTKRDDAKY MYYLKKFIME TLKAIKLDGV DVIGYTAWSL MDGFEWHRGY SIRRGLFYVD 
481:	FLSQDKMLLP KSSALFYQKL IEKNGFPPLP ENQPLEGTFP CDFAWGVVDN YIQVDTTLSQ 
541:	FTDLNVYLWD VHHSKRLIKV DGVVTKKRKS YCVDFAAIQP QIALLQEMHV THFRFSLDWA 
601:	LILPLGNQSQ VNHTILQYYR CMASELVRVN ITPVVALWQP MAPNQGLPRL LARQGAWENP 
661:	YTALAFAEYA RLCFQELGHH VKLWITMNEP YTRNMTYSAG HNLLKAHALA WHVYNEKFRH 
721:	AQNGKISIAL QADWIEPACP FSQKDKEVAE RVLEFDIGWL AEPIFGSGDY PWVMRDWLNQ 
781:	RNNFLLPYFT EDEKKLIQGT FDFLALSHYT TILVDSEKED PIKYNDYLEV QEMTDITWLN 
841:	SPSQVAVVPW GLRKVLNWLK FKYGDLPMYI ISNGIDDGLH AEDDQLRVYY MQNYINEALK 
901:	AHILDGINLC GYFAYSFNDR TAPRFGLYRY AADQFEPKAS MKHYRKIIDS NGFPGPETLE 
961:	RFCPEEFTVC TECSFFHTRK SLLAFIAFLF FASIISLSLI FYYSKKGRRS YK