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8.A.53.1.1
Barttin of 320 aas and 2 N-terminal TMSs.  Barttin is an auxillary subunit of the α-subunit of the K+-dependent chloride channels, designated CLC-K, BSND and BART (see TC# 2.A.49.2.4-5) (Wojciechowski et al. 2015). Barttin stabilizes the ClC-K/barttin complex, promotes its insertion into the surface membrane, and turns the pore-forming subunits into a conductive state. The N-terminal domain of barttin is essential for its activity (Wojciechowski et al. 2018). The protein is associated with Bartter's disease (Elrharchi et al. 2018).

Accession Number:Q8WZ55
Protein Name:Barttin
Length:320
Molecular Weight:35197.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADEKTFRIG FIVLGLFLLA LGTFLMSHDR PQVYGTFYAM GSVMVIGGII WSMCQCYPKI 
61:	TFVPADSDFQ GILSPKAMGL LENGLAAEMK SPSPQPPYVR LWEEAAYDQS LPDFSHIQMK 
121:	VMSYSEDHRS LLAPEMGQPK LGTSDGGEGG PGDVQAWMEA AVVIHKGSDE SEGERRLTQS 
181:	WPGPLACPQG PAPLASFQDD LDMDSSEGSS PNASPHDREE ACSPQQEPQG CRCPLDRFQD 
241:	FALIDAPTLE DEPQEGQQWE IALPNNWQRY PRTKVEEKEA SDTGGEEPEK EEEDLYYGLP 
301:	DGAGDLLPDK ELGFEPDTQG