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8.A.55.1.1
IZUMO sperm-egg fusion protein 1of 350 aas and 2 TMSs (N- and C-termini). Essential sperm cell-surface protein required for fertilization by acting as a ligand for the IZUMO1R/JUNO receptor on the egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (Inoue et al. 2013). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (Klinovska et al. 2014).

Accession Number:Q8IYV9
Protein Name:Izumo sperm-egg fusion protein 1
Length:350
Molecular Weight:38930.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Structure:
5F4E   5F4T   5F4V   5JK9   5JKC   5JKD   5JKE     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH KAMMERVENA 
61:	VKDFQELSLN EDAYMGVVDE ATLQKGSWSL LKDLKRITDS DVKGDLFVKE LFWMLHLQKE 
121:	TFATYVARFQ KEAYCPNKCG VMLQTLIWCK NCKKEVHACR KSYDCGERNV EVPQMEDMIL 
181:	DCELNWHQAS EGLTDYSFYR VWGNNTETLV SKGKEATLTK PMVGPEDAGS YRCELGSVNS 
241:	SPATIINFHV TVLPKMIKEE KPSPNIVTPG EATTESSISL QPLQPEKMLA SRLLGLLICG 
301:	SLALITGLTF AIFRRRKVID FIKSSLFGLG SGAAEQTQVP KEKATDSRQQ