TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.68.1.1









Endosomal membrane protein 70, TMN2p (EMP70 superfamily) with an N-terminal hydrophilic domain and a 9 TMS C-terminal domain. The hydrophilic N-terminal domain is in the lumen of the cytoplasmic membrane.  Suggested to be a channel or small molecule transporter (Schimmöller et al. 1998).

Eukaryota
Fungi
TMN2p of Saccharomyces cerevisiae (E7NFP9)
8.A.68.1.2









TMN7

Eukaryota
Viridiplantae
TMN7 of Arabidopsis thaliana (Q9LIC2)
8.A.68.1.3









TM9SF4 protein (expressed in acidic vesicles of metastatic melanoma cells; not identified in normal cells) (1+2+2+2+2 TMS arrangement) (Lozupone et al. 2009; Lozupone et al. 2015). TM9SF4 controls the sorting of TMDs at the ER-Golgi interface, although TM9SF1 (TC# 8.A.68.1.13), while associating with several TMDs, did not visibly alter their intracellular transport and may therefore function in another intracellular transport pathway (Vernay et al. 2018).

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Eukaryota
Metazoa
TM9SF4 of Homo sapiens (Q92544)
8.A.68.1.4









Putative phagocytic receptor 1A (Phg1A). Required for cellular immunity via cell adhesion and phagoytosis (Bergeret et al. 2008). (possibly a member of the ion transporter (IT) superfamily, but not confirmed)

Eukaryota
Dictyosteliida
Phyg1A of Dictyostelium discoideum (Q55FP0)
8.A.68.1.5









Syntaxin, SYP111.

Eukaryota
Viridiplantae
Syntaxin of Oryza sativa (Q84LF6)
8.A.68.1.6









Transmembrane 9 superfamily member 2 (p76).  Possibly involved in spermatogenesis (Bonache et al. 2014).

Eukaryota
Metazoa
TM9SF2 of Homo sapiens
8.A.68.1.7









Golgi endomembrane protein, EMP70 precursor (Gao et al. 2012).

Eukaryota
Viridiplantae
EMP70 of Arabidopsis thaliana
8.A.68.1.8









TM9SF1 of 609 aas and 9 putative TMSs (Pruvot et al. 2010).

Eukaryota
Metazoa
TM9SF1 of Danio rerio (Zebrafish) (Brachydanio rerio)
8.A.68.1.9









TM9SF2 of 659 aas and 9 TMSs.  Regulates (with TM9SF4) plasma membrane localization and signalling activity of the peptidoglycan recognizing protein, PGRP-LC (Perrin et al. 2015).

Eukaryota
Metazoa
TM9SF2 of Drosophila melanogaster (Fruit fly)
8.A.68.1.10









TM9SF4 of 630 aas and 9 TMSs.  Regulates (with TM9SF2) plasma membrane localization and signalling activity of the peptidoglycan recognizing protein, PGRP-LC (Perrin et al. 2015).

Eukaryota
Metazoa
TM9SF4 of Drosophila melanogaster (Fruit fly)
8.A.68.1.11









Uncharacterized TM9 family member of 730 aas and 10 TMSs.

Eukaryota
Fungi
UP of Tetrapisispora phaffii (Yeast) (Fabospora phaffii)
8.A.68.1.12









TM9SF member of 650 aas and 10 TMSs.

Eukaryota
Intramacronucleata
TM9SF family member of Tetrahymena thermophila
8.A.68.1.13









TM9SF1 of 606 aas and 9 or 10 TMSs. Functions in the regulation of autophagy (He et al. 2009).

Eukaryota
Metazoa
TM9SF1 of Homo sapiens
8.A.68.1.14









The Gm364 protein of 671 aas and 10 TMSs in a 1 + 1 + 2 + 2 + 2 + 2 TMS arrangement. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation (Chen et al. 2021). Global knockout of Gm364 decreased the numbers of primordial follicles and growing follicles, impaired oocyte quality as indicated by increased ROS and gamma-H2AX, decreased mitochondrial membrane potential, decreased oocyte maturation, and increased aneuploidy. Mechanistically, Gm364 directly binds and anchors MIB2, a ubiquitin ligase, on the membrane. Subsequently, membrane MIB2 ubiquitinates and activates DLL3. Next, the activated DLL3 binds and activates Notch2, which is subsequently cleaved within the cytoplasm to produce NICD2, the intracellular active domain of Notch2. Finally, NICD2 can directly activate AKT within the cytoplasm to regulate oocyte meiosis and quality (Chen et al. 2021).

Eukaryota
Opisthokonta
Gm364 of Mus musculus
8.A.68.1.15









Putative RNA polymerase II C-terminal domain, phosphatase-like 2 of 835 aas and and N-terminal 5 or 6 TMSs in a 1 + 2 + 2 or 2 + 2 + 2 TMS arrangment.

Eukaryota
Viridiplantae
Putative RNA polymerase subunit of Senna tora  
8.A.68.1.16









Uncharacterized protein of 696 aas and 6 TMSs.

Eukaryota
Opisthokonta
UP of Ascoidea rubescens
8.A.68.1.17









Transmembrane 9 superfamily member 5-like isoform X2 of 555 aas and 9 TMSs with a 200 aa hydrophilic domain followed by 5 TMSs followed by 4 more TMSs.

Eukaryota
Viridiplantae
TM9 family protein of Cucurbita maxima