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8.A.68.1.6
Transmembrane 9 superfamily member 2 (p76).  Possibly involved in spermatogenesis (Bonache et al. 2014).

Accession Number:Q99805
Protein Name:Transmembrane 9 superfamily member 2
Length:663
Molecular Weight:75776.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q99805
eggNOG: NOG315241
HEGENOM: HOG000216679
Entrez Gene ID: 9375   
Pfam: PF02990   
KEGG: hsa:9375   

Gene Ontology

GO:0005768 C:endosome
GO:0010008 C:endosome membrane
GO:0005887 C:integral to plasma membrane
GO:0006810 P:transport

References (5)

[1] “Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution.”  Schimmoeller F.et.al.   9729438
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSARLPVLSP PRWPRLLLLS LLLLGAVPGP RRSGAFYLPG LAPVNFCDEE KKSDECKAEI 
61:	ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL FGERIEPSPY KFTFNKKETC 
121:	KLVCTKTYHT EKAEDKQKLE FLKKSMLLNY QHHWIVDNMP VTWCYDVEDG QRFCNPGFPI 
181:	GCYITDKGHA KDACVISSDF HERDTFYIFN HVDIKIYYHV VETGSMGARL VAAKLEPKSF 
241:	KHTHIDKPDC SGPPMDISNK ASGEIKIAYT YSVSFEEDDK IRWASRWDYI LESMPHTHIQ 
301:	WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL VHGDIFRPPR 
361:	KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM TCAVVLWVLL GTPAGYVAAR 
421:	FYKSFGGEKW KTNVLLTSFL CPGIVFADFF IMNLILWGEG SSAAIPFGTL VAILALWFCI 
481:	SVPLTFIGAY FGFKKNAIEH PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF 
541:	FILNSIWSHQ MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA 
601:	VYFLIYAVHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF WFVTKIYSVV 
661:	KVD