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8.A.69.1.1
BH3-only protein, also called Bcl-2-like protein 11, Bim, of 198 aas and 1 C-terminal TMS; induces apoptosis and anoikis (Fukazawa et al. 2004). Different isoforms have differing activities (Marani et al. 2002). Isoform Bim-alpha3 induces apoptosis, possibly through a caspase-mediated pathway, but isoforms BimAC and BimABC lack the ability to induce apoptosis.

Accession Number:O43521
Protein Name:Bcl-2-like protein 11
Length:198
Molecular Weight:22171.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion1
Substrate NONE

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP 
61:	QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP 
121:	CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR 
181:	MVILRLLRYI VRLVWRMH