TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.82.1.1









Calmodulin regulates various channels, including several voltage-gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors, calcium channels dependent on cyclic nucleotides, and those located in the endoplasmic reticulum such as ryanodine receptors and all isoforms of IP3-dependent receptors (Rebas et al. 2012).  It also mediates secretion in animals of small intron-less proteins (Shao and Hegde, 2011).

Eukaryota
Metazoa
Calmodulin of Homo sapiens (P62158)
*8.A.82.1.2









Calretinin (Calbindin) of 271 aas and no TMS.  Plays a role in the regulation of cytoplasmic calcium concentrations.  It is a calcium-binding protein abundant in auditory neurons.

Eukaryota
Metazoa
Calretinin of Homo sapiens
*8.A.82.1.3









Calmodulin-like protein, CML6, of 154 aas. May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

Eukaryota
Viridiplantae
CML6 of Arabidopsis thaliana (Mouse-ear cress)
*8.A.82.1.4









Calmodulin-like protein, CaM, of 151 aas,

Eukaryota
Metazoa
CaM of Drosophila melanogaster (Fruit fly)
*8.A.82.1.5









Uncharacterized protein of 148 aas

Eukaryota
Fungi
UP of Cladophialophora yegresii
*8.A.82.1.6









Calcineurin B-like protein of 195 aas, CHP1 or CHP.

Eukaryota
Metazoa
CHP1 of Homo sapiens
*8.A.82.1.7









RCaMP of 432 aas and 0 TMSs. GCaMP, containing a C-terminal CaM (calmodulin) domain, interferes with both gating and signaling of L-type calcium channels (CaV1). GCaMP acts as an impaired apoCaM and Ca2+/CaM, both critical to CaV1 (Yang et al. 2018).

Eukaryota
Metazoa
RCaMP of Entacmaea quadricolor (Bubble-tip anemone) (Parasicyonis actinostoloides)
*8.A.82.2.1









Calcineurin B-like protein 8
Eukaryota
Viridiplantae
Arabidopsis thaliana
*8.A.82.2.2









Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4).  These proteins have N-terminal variants due to the presence of multiple start sites (Jerng and Pfaffinger 2014).

Eukaryota
Metazoa
KCNIP4 of Homo sapiens
*8.A.82.2.3









Salt overly sensitive-3, SOS3 of 222 aas.  The salt stress-induced SALT-OVERLY-SENSITIVE (SOS) pathway in Arabidopsis thaliana involves the perception of a calcium signal by the SOS3 and SOS3-like CALCIUM-BINDING PROTEIN8 (SCaBP8) calcium sensors, which then interact with and activate the SOS2 protein kinase (9.B.106.3.4), forming a complex at the plasma membrane that activates the SOS1 Na⁺/H⁺ exchanger (2.A.36.7.6) (Lin et al. 2014Lin et al. 2014).

Eukaryota
Viridiplantae
SOS3 of Arabidopsis thaliana
*8.A.82.2.4









The KCNIP2 or KCHIP2 protein of 270 aas, a regulator and subunit of K+ channels such as Kv4.3 and Kv1.4 as well as cardiac L-type Ca+ channels (Thomsen et al. 2009; Hovind et al. 2011; Wang et al. 2013).

 

Eukaryota
Metazoa
KCHIP2 of Homo sapiens
*8.A.82.2.5









Calsenilin (KCHIP3, KCNIP3, CSEN, DREAM) of 256 aas and 0 TMSs.  Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (Jerng and Pfaffinger 2008). Interacts with TRPV1 (TC# 1.A.4.2.1) and alleviates inflammatory hyperalgesia (Tian et al. 2018). IQM-266 is a chemical that may allow a better understanding of DREAM physiological role as well as modulation of neuronal I A in pathological processes (Peraza et al. 2019).

 

Eukaryota
Metazoa
Calsenilin of Homo sapiens
*8.A.82.2.6









Kv channel-interacting protein, KChIP-1 or KCNIP1 of 227 aas and 0 TMSs.  It is a regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. It regulates channel density and influences inactivation kinetics and the rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, it modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents and increases the presence of KCND2 at the cell surface (Wang et al. 2007; An et al. 2000).

Eukaryota
Metazoa
KChIP-1 of Homo sapiens
*8.A.82.2.7









Recoverin, of 200 aas, has been mplicated in the pathway from retinal rod guanylate cyclase to rhodopsin. It may be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner as the calcium-bound recoverin prolongs the photoresponse. It is a myristoylated protein, and myristoylation causes membrane association (Brand and Koch 2018).


Eukaryota
Metazoa
Recoverin of Homo sapiens
*8.A.82.3.1









45 kDa Ca2+-binding protein of 362 aas with an N-terminal TMS, SDF4 or CAB45. Cab45 mediates sorting of a subset of secretory proteins at the trans-Golgi network. In response to Ca2+ influx, Cab45 forms oligomers, enabling it to bind a variety of specific cargo molecules (Blank and von Blume 2017). It has an internal repeat involving residues 47 - 163 and residues 210 - 347.

 

Eukaryota
Metazoa
CAB45 of Homo sapiens
*8.A.82.3.2









Reticulocalbin-2 (calumenin-like protein) of 405 aas and 1 N-terminal TMS. These proteins are characterized by at least one EF-hand calcium binding motif, and they belong to a diverse superfamily of calcium sensors and calcium signal modulators. Most members have 2 active canonical EF hands.

Eukaryota
Viridiplantae
Reticulocalbin-2 of Vigna radiata
*8.A.82.4.1









EF-hand calcium-binding domain-containing protein 3, EFCAB3, of 438 aas and 0 TMSs (Zhang et al. 2018).

Eukaryota
Metazoa
EFCAB3 of Homo sapiens