TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.9.1.1









rBAT of 677 aas and 1 TMS.  This protein is identical to the human ortholog. Computational analyses have identifies druggable mutations in human rBAT that mediate Cystinuria (Pandey et al. 2020).

Eukaryota
Metazoa
rBAT of Oryctolagus cuniculus
8.A.9.1.2









Neutral and basic amino acid transport protein rBAT (NBAT) (B(0,+)-type amino acid transport protein) (D2h)
Eukaryota
Metazoa
SLC3A1 of Homo sapiens
8.A.9.1.3









Cell surface alpha-amylase (α-amylase), SusG of 692 aas and 1 N-terminal TMS.  It forms a complex with SusCDEF, which are all outer membrane porins. SusC is 1.B.14.6.1; SusD is 1.B.38.1.10; SusE is 1.B.38.4.1, and SusF is 1.B.38.4.2. They form a complex for the hydrolysis of starch (amylose) and the uptake of maltooligosaccharides into the periplasm of the cell (Foley et al. 2018). 

Bacteria
Bacteroidetes
SusG of Bacteroides thetaiotaomicron
8.A.9.2.1









4F2hc of 527 aas and 1 TMS.  The 4F2/CDC98 cell surface receptor is involved in internalization of beta-defensin 3 (Colavita et al. 2015).

Eukaryota
Metazoa
4F2hc of Rattus norvegicus
8.A.9.2.2









The Slc3A2 (CD98hc; 4F2hc) accessory protein facilitates transport of amino acids and polyamines (putrescine/spermidine) (Uemura et al. 2008). 4F2hc stabilizes GLUT1 (2.A.1.1.28) and increase glucose transport activity (Ohno et al., 2011).  It forms a heterodimer with glycoprotein CD98 (LAT1; SLC7A5), and contributes to tumorigenesis (Estrach et al. 2014).  CD98hc also modulates integrin signaling, plays a role in cell-to-cell fusion, and is essential for Brucella infection (Keriel et al. 2015). Hepatitis C virus (HCV) exploits SLC3A2 for viral propagation, and upregulation of SLC3A2 may contribute to HCV-mediated pathogenesis (Nguyen et al. 2018). ZEB1, a transcriptional repressor (P37275), promotes chemoresistance to cisplatin in ovarian cancer cells by suppressing SLC3A2 (Cui et al. 2018). SLC3A2/CD98hc and its light chain subunits constitute the heterodimeric transmembrane complexes that mediate amino acid transport and regulate MTOR and macroautophagy/autophagy (Digomann et al. 2019). It forms a tight complex with beta1 integrin (TC# 9.B.87.1.8) and TrpV4 (TC# 1.A.4.2.5) in focal adhesions where mechanochemical conversion takes place. CD98hc knock down inhibits TRPV4-mediated calcium influx induced by mechanical forces, but not by chemical activators, thus confirming the mechanospecificity of this signaling response. Molecular analysis revealed that forces applied to beta1 integrin must be transmitted from its cytoplasmic C-terminus via the CD98hc cytoplasmic tail to the ankyrin repeat domain of TRPV4 in order to produce ultra-rapid, force-induced, channel activation within the focal adhesion (Potla et al. 2020).

Eukaryota
Metazoa
SLC3A2 of Homo sapiens
8.A.9.2.3









CD98hc, heavy chain of the heterodimeric CD998 (CG2791) amino acid transporter; involved in cell fusion, cell adhesion, TOR signalling, and amino acid transprot via LAT1 and LAT2 (see TC# 2.A.3.8.32) (Reynolds et al. 2009). CD98hc combines with one of six CD98lc proteins to regulate vascular smooth muscle cell proliferation in atherosclerosis (Baumer et al. 2017).

Eukaryota
Metazoa
CD98hc of Drosophila melanogaster (Fruit fly)
8.A.9.3.1









Eukaryota
Metazoa
SPRM1hc of Schistosoma japonicum (Q5DDT5)