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8.A.92.1.4
Receptor of activated protein C kinase 1 of 317 aas and 0 TMSs. Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. It is nvolved in PKC-dependent translocation of ADAM12 to the cell membrane and promotes ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. It is required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. It regulates internalization of the muscarinic receptor CHRM2 and promotes apoptosis by increasing oligomerization of BAX while disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. It inhibits TRPM6 channel activity and regulates cell surface expression of some GPCRs. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (Ikebuchi et al. 2009).

Accession Number:P63244
Protein Name:Receptor of activated protein C kinase 1
Length:317
Molecular Weight:35077.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate

Cross database links:

Structure:
4AOW   4UG0   4V6X   5A2Q   5AJ0   5FLX   5LKS   5OA3   5T2C   5VYC   [...more]

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 
61:	GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI 
121:	VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA 
181:	NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC 
241:	FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA 
301:	GYTDNLVRVW QVTIGTR