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8.A.93.1.1
TMEM97 protein (the sigma2 receptor; Mac30; S2R) of 176 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement (Alon et al. 2017).  It is an ER resident protein that regulates the sterol transporter, NPC1 (TC# 2.A.6.6.1). It is involved in diseases as diverse as cancer and neurological disorders (Alon et al. 2017).  TMEM97 possesses the full suite of molecular properties that define the sigma2 receptor, and Asp29 and Asp56 are essential for ligand recognition (Alon et al. 2017). It is regulated by a number of drugs (Intagliata et al. 2020).

Accession Number:Q5BJF2
Protein Name:Transmembrane protein 97
Length:176
Molecular Weight:20848.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Nucleus membrane1
Substrate

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGAPATRRCV EWLLGLYFLS HIPITLFMDL QAVLPRELYP VEFRNLLKWY AKEFKDPLLQ 
61:	EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA IIYSVHTMTT LIPILSTFLF 
121:	EDFSKASGFK GQRPETLHER LTLVSVYAPY LLIPFILLIF MLRSPYYKYE EKRKKK