TMEM97 protein (the sigma2 receptor; Mac30; S2R) of 176 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement (Alon et al. 2017). It is an ER resident protein that regulates the sterol transporter, NPC1 (TC# 2.A.6.6.1). It is involved in diseases as diverse as cancer and neurological disorders (Alon et al. 2017). TMEM97 possesses the full suite of molecular properties that define the sigma2 receptor, and Asp29 and Asp56 are essential for ligand recognition (Alon et al. 2017). It is regulated by a number of drugs (Intagliata et al. 2020).
|Protein Name:||Transmembrane protein 97|
|Species:||Homo sapiens (Human)  |
|Number of TMSs:||4|
|Location1 / Topology2 / Orientation3:
1: MGAPATRRCV EWLLGLYFLS HIPITLFMDL QAVLPRELYP VEFRNLLKWY AKEFKDPLLQ
61: EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA IIYSVHTMTT LIPILSTFLF
121: EDFSKASGFK GQRPETLHER LTLVSVYAPY LLIPFILLIF MLRSPYYKYE EKRKKK