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8.A.93.2.1
Transmembrane 6 superfamily 2 (TM6SF2) of 377 aas and 9 or 10 TMSs; it regulates plasma lipids. TM6SF2 variants are associated with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD) (Li et al. 2018). The mechanisms underlying TM6SF2 regulation of lipid metabolism, involving intestinal cholesterol absorption and hepatic cholesterol biosynthesis and transport, have been discussed (Li et al. 2018).

Accession Number:Q9BZW4
Protein Name:Transmembrane 6 superfamily member 2
Length:377
Molecular Weight:42554.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDIPPLAGKI AALSLSALPV SYALNHVSAL SHPLWVALMS ALILGLLFVA VYSLSHGEVS 
61:	YDPLYAVFAV FAFTSVVDLI IALQEDSYVV GFMEFYTKEG EPYLRTAHGV FICYWDGTVH 
121:	YLLYLAMAGA ICRRKRYRNF GLYWLGSFAM SILVFLTGNI LGKYSSEIRP AFFLTIPYLL 
181:	VPCWAGMKVF SQPRALTRCT ANMVQEEQRK GLLQRPADLA LVIYLILAGF FTLFRGLVVL 
241:	DCPTDACFVY IYQYEPYLRD PVAYPKVQML MYMFYVLPFC GLAAYALTFP GCSWLPDWAL 
301:	VFAGGIGQAQ FSHMGASMHL RTPFTYRVPE DTWGCFFVCN LLYALGPHLL AYRCLQWPAF 
361:	FHQPPPSDPL ALHKKQH