TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.97.1.1









The vacuolar membrane protein 1, VMP1 (also called TDC1, TMEM49 and HSPC 292) of 406 aas and 8 - 10 TMSs (possibly in a 3 + 1 + 3 + 1 TMS arrangement. It is a regulator of the SERCA Ca2+-ATPase (Zhao et al. 2017). However, the release of lipoproteins from the ER membrane requires VMP1, an ER transmembrane protein essential for autophagy and certain types of secretion (Morishita et al. 2019). Loss of Vmp1, but not other autophagy-related proteins, in zebrafish causes lipoprotein accumulation in the intestine and liver. Vmp1 deficiency in mice also leads to lipid accumulation in the visceral endoderm and intestine. In VMP1-depleted cells, neutral lipids accumulate within lipid bilayers of the ER membrane, thus affecting lipoprotein secretion. Thus, VMP1 may mediate the release of lipoproteins from the ER membrane to the ER lumen (Morishita et al. 2019).

Eukaryota
Metazoa
VMP1 of Homo sapiens
8.A.97.1.2









The Ectopic P-granules Protein 3, EPG3, of 458 aas and 8 - 10 TMSs (Tian et al. 2010; Manil-Ségalen et al. 2014Manil-Ségalen et al. 2014).  Contains a DedA domain (TC# 9.A.27).

Eukaryota
Metazoa
EPG3 of Caenorhabditis elegans
8.A.97.1.3









Uncharacterized protein of 421 aas and 6 - 9 TMSs.

Eukaryota
Viridiplantae
UP of Volvox carteri
8.A.97.1.4









Uncharacterized protein of 504 aas and 7 - 9 TMSs.

Eukaryota
Isochrysidales
UP of Emiliania huxleyi (Pontosphaera huxleyi)