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8.A.97.1.1
The vacuolar membrane protein 1, VMP1 (also called TDC1, TMEM49 and HSPC 292) of 406 aas and 8 - 10 TMSs (possibly in a 3 + 1 + 3 + 1 TMS arrangement. It is a regulator of the SERCA Ca2+-ATPase (Zhao et al. 2017). However, the release of lipoproteins from the ER membrane requires VMP1, an ER transmembrane protein essential for autophagy and certain types of secretion (Morishita et al. 2019). Loss of Vmp1, but not other autophagy-related proteins, in zebrafish causes lipoprotein accumulation in the intestine and liver. Vmp1 deficiency in mice also leads to lipid accumulation in the visceral endoderm and intestine. In VMP1-depleted cells, neutral lipids accumulate within lipid bilayers of the ER membrane, thus affecting lipoprotein secretion. Thus, VMP1 may mediate the release of lipoproteins from the ER membrane to the ER lumen (Morishita et al. 2019).

Accession Number:Q96GC9
Protein Name:Vacuole membrane protein 1
Length:406
Molecular Weight:46238.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endoplasmic reticulum-Golgi intermediate compartment membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAENGKNCDQ RRVAMNKEHH NGNFTDPSSV NEKKRREREE RQNIVLWRQP LITLQYFSLE 
61:	ILVILKEWTS KLWHRQSIVV SFLLLLAVLI ATYYVEGVHQ QYVQRIEKQF LLYAYWIGLG 
121:	ILSSVGLGTG LHTFLLYLGP HIASVTLAAY ECNSVNFPEP PYPDQIICPD EEGTEGTISL 
181:	WSIISKVRIE ACMWGIGTAI GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAESAQDF 
241:	ASRAKLAVQK LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK 
301:	MHIQKIFVII TFSKHIVEQM VAFIGAVPGI GPSLQKPFQE YLEAQRQKLH HKSEMGTPQG 
361:	ENWLSWMFEK LVVVMVCYFI LSIINSMAQS YAKRIQQRLN SEEKTK