8.B.14.2.2 Matrix metalloproteinase-23, MMP23B, (ADAM23, MMP21 or MMP22) of 390 aas. It regulates the surface expression of several potassium channels by retaining them in the endoplasmic reticulum (Ohnishi et al. 2001; Costa et al. 2015). ADAM22 and ADAM23 have opposite effects on Kv1.1/Kv1.4 currents, ADAM23 inhbiting and ADAM22 activating. The relative expression of these proteins may shape the expression of K+ currents in different neuronal membrane domains (Lancaster et al. 2019).
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Accession Number: | O75900 |
Protein Name: | Matrix metalloproteinase-23 |
Length: | 390 |
Molecular Weight: | 43935.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type II membrane protein2 |
Substrate |
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1: MGRGARVPSE APGAGVERRW LGAALVALCL LPALVLLARL GAPAVPAWSA AQGDVAALGL
61: SAVPPTRVPG PLAPRRRRYT LTPARLRWDH FNLTYRILSF PRNLLSPRET RRALAAAFRM
121: WSDVSPFSFR EVAPEQPSDL RIGFYPINHT DCLVSALHHC FDGPTGELAH AFFPPHGGIH
181: FDDSEYWVLG PTRYSWKKGV WLTDLVHVAA HEIGHALGLM HSQHGRALMH LNATLRGWKA
241: LSQDELWGLH RLYGCLDRLF VCASWARRGF CDARRRLMKR LCPSSCDFCY EFPFPTVATT
301: PPPPRTKTRL VPEGRNVTFR CGQKILHKKG KVYWYKDQEP LEFSYPGYLA LGEAHLSIIA
361: NAVNEGTYTC VVRRQQRVLT TYSWRVRVRG