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8.B.14.2.2
Matrix metalloproteinase-23, MMP23B, (ADAM23, MMP21 or MMP22) of 390 aas. It regulates the surface expression of several potassium channels by retaining them in the endoplasmic reticulum (Ohnishi et al. 2001; Costa et al. 2015). ADAM22 and ADAM23 have opposite effects on Kv1.1/Kv1.4 currents, ADAM23 inhbiting and ADAM22 activating. The relative expression of these proteins may shape the expression of K+ currents in different neuronal membrane domains (Lancaster et al. 2019).  

Accession Number:O75900
Protein Name:Matrix metalloproteinase-23
Length:390
Molecular Weight:43935.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Single-pass type II membrane protein2
Substrate

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FASTA formatted sequence 
1:	MGRGARVPSE APGAGVERRW LGAALVALCL LPALVLLARL GAPAVPAWSA AQGDVAALGL 
61:	SAVPPTRVPG PLAPRRRRYT LTPARLRWDH FNLTYRILSF PRNLLSPRET RRALAAAFRM 
121:	WSDVSPFSFR EVAPEQPSDL RIGFYPINHT DCLVSALHHC FDGPTGELAH AFFPPHGGIH 
181:	FDDSEYWVLG PTRYSWKKGV WLTDLVHVAA HEIGHALGLM HSQHGRALMH LNATLRGWKA 
241:	LSQDELWGLH RLYGCLDRLF VCASWARRGF CDARRRLMKR LCPSSCDFCY EFPFPTVATT 
301:	PPPPRTKTRL VPEGRNVTFR CGQKILHKKG KVYWYKDQEP LEFSYPGYLA LGEAHLSIIA 
361:	NAVNEGTYTC VVRRQQRVLT TYSWRVRVRG