| |
|---|---|
| Accession Number: | P08100 |
| Protein Name: | Rhodopsin |
| Length: | 348 |
| Molecular Weight: | 38893.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | hydron, all-trans-retinal |
Cross database links:
| Entrez Gene ID: | 6010 |
|---|---|
| Pfam: | PF00001 PF10413 |
| KEGG: | hsa:6010 hsa:6010 |
Gene Ontology
GO:0005794
C:Golgi apparatus
GO:0005887
C:integral to plasma membrane
GO:0060342
C:photoreceptor inner segment membrane
GO:0042622
C:photoreceptor outer segment membrane
GO:0004930
F:G-protein coupled receptor activity
GO:0046872
F:metal ion binding
GO:0009881
F:photoreceptor activity
GO:0005515
F:protein binding
GO:0018298
P:protein-chromophore linkage
GO:0016056
P:rhodopsin mediated signaling pathway
| |
References (66)[1] “Isolation and nucleotide sequence of the gene encoding human rhodopsin.” Nathans J.et.al. 6589631 [2] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene.” Bennett J.et.al. 8566799 [5] “Rhodopsin mutations in autosomal dominant retinitis pigmentosa.” Al-Maghtheh M.et.al. 8401533 [6] “Autosomal dominant retinitis pigmentosa: absence of the rhodopsin proline-->histidine substitution (codon 23) in pedigrees from Europe.” Farrar G.J.et.al. 2239971 [7] “A point mutation of the rhodopsin gene in one form of retinitis pigmentosa.” Dryja T.P.et.al. 2137202 [8] “Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.” Dryja T.P.et.al. 2215617 [9] “A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa.” Inglehearn C.F.et.al. 1985460 [10] “Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis.” Sheffield V.C.et.al. 1897520 [11] “Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa.” Gal A.et.al. 1840561 [12] “Rhodopsin mutations in autosomal dominant retinitis pigmentosa.” Sung C.H.et.al. 1862076 [13] “Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa.” Dryja T.P.et.al. 1833777 [14] “Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family.” Farrar G.J.et.al. 1302614 [15] “Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP).” Fujiki K.et.al. 1391967 [16] “Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin.” Macke J.P.et.al. 8317502 [17] “Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsin.” Kranich H.et.al. 8353500 [18] “Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness.” Dryja T.P.et.al. 8358437 [19] “Further screening of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.” Vaithinathan R.et.al. 8088850 [20] “Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosa.” Reig C.et.al. 8076945 [21] “Three novel rhodopsin mutations (C110F, L131P, A164V) in patients with autosomal dominant retinitis pigmentosa.” Fuchs S.et.al. 7981701 [22] “Identification of a new mutation at codon 171 of rhodopsin gene causing autosomal dominant retinitis pigmentosa.” Antinolo G.et.al. 7987326 [23] “Five novel missense mutations of the rhodopsin gene in autosomal dominant retinitis pigmentosa.” Souied E.et.al. 7987331 [24] “Two new rhodopsin transversion mutations (L40R; M216K) in families with autosomal dominant retinitis pigmentosa.” Al-Maghtheh M.et.al. 8081400 [25] “Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study.” Rosas D.J.et.al. 8045708 [26] “Missense rhodopsin mutation in a family with recessive RP.” Kumaramanickavel G.et.al. 7987385 [27] “Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347.” Macke J.P.et.al. 7633434 [28] “Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.” Sieving P.A.et.al. 7846071 [29] “Retinitis punctata albescens associated with the Arg135Trp mutation in the rhodopsin gene.” Souied E.et.al. 8554077 [30] “Rhodopsin mutation G109R in a family with autosomal dominant retinitis pigmentosa.” Goliath R.et.al. 9452035 [31] “A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness.” Al-Jandal N.et.al. 9888392 [32] “A dual role for EDEM1 in the processing of rod opsin.” Kosmaoglou M.et.al. 19934218 [33] “A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa.” Azam M.et.al. 19960070 [34] “Isolation and nucleotide sequence of the gene encoding human rhodopsin.” Nathans J.et.al. 6589631 [35] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [36] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [37] “Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene.” Bennett J.et.al. 8566799 [38] “Rhodopsin mutations in autosomal dominant retinitis pigmentosa.” Al-Maghtheh M.et.al. 8401533 [39] “Autosomal dominant retinitis pigmentosa: absence of the rhodopsin proline-->histidine substitution (codon 23) in pedigrees from Europe.” Farrar G.J.et.al. 2239971 [40] “A point mutation of the rhodopsin gene in one form of retinitis pigmentosa.” Dryja T.P.et.al. 2137202 [41] “Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.” Dryja T.P.et.al. 2215617 [42] “A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa.” Inglehearn C.F.et.al. 1985460 [43] “Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis.” Sheffield V.C.et.al. 1897520 [44] “Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa.” Gal A.et.al. 1840561 [45] “Rhodopsin mutations in autosomal dominant retinitis pigmentosa.” Sung C.H.et.al. 1862076 [46] “Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa.” Dryja T.P.et.al. 1833777 [47] “Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family.” Farrar G.J.et.al. 1302614 [48] “Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP).” Fujiki K.et.al. 1391967 [49] “Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin.” Macke J.P.et.al. 8317502 [50] “Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsin.” Kranich H.et.al. 8353500 [51] “Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness.” Dryja T.P.et.al. 8358437 [52] “Further screening of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.” Vaithinathan R.et.al. 8088850 [53] “Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosa.” Reig C.et.al. 8076945 [54] “Three novel rhodopsin mutations (C110F, L131P, A164V) in patients with autosomal dominant retinitis pigmentosa.” Fuchs S.et.al. 7981701 [55] “Identification of a new mutation at codon 171 of rhodopsin gene causing autosomal dominant retinitis pigmentosa.” Antinolo G.et.al. 7987326 [56] “Five novel missense mutations of the rhodopsin gene in autosomal dominant retinitis pigmentosa.” Souied E.et.al. 7987331 [57] “Two new rhodopsin transversion mutations (L40R; M216K) in families with autosomal dominant retinitis pigmentosa.” Al-Maghtheh M.et.al. 8081400 [58] “Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study.” Rosas D.J.et.al. 8045708 [59] “Missense rhodopsin mutation in a family with recessive RP.” Kumaramanickavel G.et.al. 7987385 [60] “Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347.” Macke J.P.et.al. 7633434 [61] “Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.” Sieving P.A.et.al. 7846071 [62] “Retinitis punctata albescens associated with the Arg135Trp mutation in the rhodopsin gene.” Souied E.et.al. 8554077 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNGTEGPNFY VPFSNATGVV RSPFEYPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY 61: VTVQHKKLRT PLNYILLNLA VADLFMVLGG FTSTLYTSLH GYFVFGPTGC NLEGFFATLG 121: GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLAGWSRYIP 181: EGLQCSCGID YYTLKPEVNN ESFVIYMFVV HFTIPMIIIF FCYGQLVFTV KEAAAQQQES 241: ATTQKAEKEV TRMVIIMVIA FLICWVPYAS VAFYIFTHQG SNFGPIFMTI PAFFAKSAAI 301: YNPVIYIMMN KQFRNCMLTT ICCGKNPLGD DEASATVSKT ETSQVAPA