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9.A.14.1.4
Thyrotropin-releasing hormone receptor

Accession Number:P34981
Protein Name:Thyrotropin-releasing hormone receptor
Length:398
Molecular Weight:45085.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P34981 P34981
eggNOG: NOG303917 NOG303917
HEGENOM: HBG444512 HBG444512
Entrez Gene ID: 7201   
Pfam: PF00001   
KEGG: hsa:7201    hsa:7201   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004997 F:thyrotropin-releasing hormone receptor activity

References (16)

[1] “Molecular cloning of a functional human thyrotropin-releasing hormone receptor.”  Matre V.et.al.   8395824
[2] “Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.”  Yamada M.et.al.   8396925
[3] “Cloning and functional characterisation of the human TRH receptor.”  Duthie S.M.et.al.   8243797
[4] “Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.”  Hinuma S.et.al.   7918619
[5] “Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.”  Iwasaki T.et.al.   8703031
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.”  Matre V.et.al.   9886052
[8] “A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.”  Cook J.V.et.al.   8770906
[9] “Molecular cloning of a functional human thyrotropin-releasing hormone receptor.”  Matre V.et.al.   8395824
[10] “Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.”  Yamada M.et.al.   8396925
[11] “Cloning and functional characterisation of the human TRH receptor.”  Duthie S.M.et.al.   8243797
[12] “Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.”  Hinuma S.et.al.   7918619
[13] “Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.”  Iwasaki T.et.al.   8703031
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.”  Matre V.et.al.   9886052
[16] “A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.”  Cook J.V.et.al.   8770906

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV MRTKHMRTPT 
61:	NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT 
121:	IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSLYCMLW FFLLDLNIST YKDAIVISCG 
181:	YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH 
241:	QNTNLNVNTS NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW 
301:	FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV ALNYSVIKES 
361:	DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS