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9.A.14.1.5
Follicle-stimulating hormone receptor

Accession Number:P23945
Protein Name:Follicle-stimulating hormone receptor
Length:695
Molecular Weight:78265.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2

Cross database links:

Genevestigator: P23945 P23945
eggNOG: NOG285844 NOG285844
HEGENOM: HBG444089 HOG000045902
Entrez Gene ID: 2492   
Pfam: PF00001    PF12369    PF01462   
KEGG: hsa:2492    hsa:2492   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004963 F:follicle-stimulating hormone receptor activity
GO:0005515 F:protein binding
GO:0007292 P:female gamete generation
GO:0008584 P:male gonad development

References (54)

[1] “Cloning and sequencing of human FSH receptor cDNA.”  Minegish T.et.al.   1709010
[2] “Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.”  Tilly J.L.et.al.   1322283
[3] “The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.”  Kelton C.A.et.al.   1301382
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.”  Gromoll J.et.al.   1359889
[8] “Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.”  Gromoll J.et.al.   7926278
[9] “Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10.”  Gromoll J.et.al.   7916967
[10] “Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.”  Jiang X.et.al.   8747461
[11] “Structure of human follicle-stimulating hormone in complex with its receptor.”  Fan Q.R.et.al.   15662415
[12] “Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.”  Aittomaeki K.et.al.   7553856
[13] “A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.”  Kotlar T.J.et.al.   9100567
[14] “An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.”  Gromoll J.et.al.   8636335
[15] “The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry.”  Jiang M.et.al.   9851774
[16] “A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.”  Beau I.et.al.   9769327
[17] “New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype.”  Touraine P.et.al.   10551778
[18] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.”  Cargill M.et.al.   10391209
[19] “Distribution and function of FSH receptor genetic variants in normal men.”  Asatiani K.et.al.   12059813
[20] “A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.”  Doherty E.et.al.   11889179
[21] “A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.”  Allen L.A.et.al.   12571157
[22] “Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies.”  Meduri G.et.al.   12915623
[23] “A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.”  Vasseur C.et.al.   12930927
[24] “Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.”  Smits G.et.al.   12930928
[25] “A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.”  Montanelli L.et.al.   15080154
[26] “Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.”  De Leener A.et.al.   16278261
[27] “Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.”  De Leener A.et.al.   17721928
[28] “Cloning and sequencing of human FSH receptor cDNA.”  Minegish T.et.al.   1709010
[29] “Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.”  Tilly J.L.et.al.   1322283
[30] “The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.”  Kelton C.A.et.al.   1301382
[31] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[32] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[33] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[34] “Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.”  Gromoll J.et.al.   1359889
[35] “Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.”  Gromoll J.et.al.   7926278
[36] “Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10.”  Gromoll J.et.al.   7916967
[37] “Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.”  Jiang X.et.al.   8747461
[38] “Structure of human follicle-stimulating hormone in complex with its receptor.”  Fan Q.R.et.al.   15662415
[39] “Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.”  Aittomaeki K.et.al.   7553856
[40] “A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.”  Kotlar T.J.et.al.   9100567
[41] “An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.”  Gromoll J.et.al.   8636335
[42] “The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry.”  Jiang M.et.al.   9851774
[43] “A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.”  Beau I.et.al.   9769327
[44] “New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype.”  Touraine P.et.al.   10551778
[45] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.”  Cargill M.et.al.   10391209
[46] “Distribution and function of FSH receptor genetic variants in normal men.”  Asatiani K.et.al.   12059813
[47] “A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.”  Doherty E.et.al.   11889179
[48] “A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.”  Allen L.A.et.al.   12571157
[49] “Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies.”  Meduri G.et.al.   12915623
[50] “A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.”  Vasseur C.et.al.   12930927
[51] “Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.”  Smits G.et.al.   12930928
[52] “A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.”  Montanelli L.et.al.   15080154
[53] “Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.”  De Leener A.et.al.   16278261
[54] “Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.”  De Leener A.et.al.   17721928

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV 
61:	IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP 
121:	NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN 
181:	GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN 
241:	LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE 
301:	VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM 
361:	GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS 
421:	VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK 
481:	VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL 
541:	AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP 
601:	LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS 
661:	TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN