TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.13.1
Type-1a angiotensin II receptor of 395 aas and 7 or 8 TMSs, AGTR1(A and B), AT2R1, AT2R1B.  A single mutation in the amphipahtic helix 8 enhances its transport and signalling (Zhu et al. 2015).

Accession Number:P30556
Protein Name:Type-1 angiotensin II receptor
Length:359
Molecular Weight:41061.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P30556
eggNOG: NOG256015
HEGENOM: HBG715940
Entrez Gene ID: 185   
Pfam: PF00001   
Drugbank: Drugbank Link   
KEGG: hsa:185   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0010698 F:acetyltransferase activator activity
GO:0001596 F:angiotensin type I receptor activity
GO:0004945 F:angiotensin type II receptor activity
GO:0031711 F:bradykinin receptor binding
GO:0046982 F:protein heterodimerization activity
GO:0019722 P:calcium-mediated signaling
GO:0060326 P:cell chemotaxis
GO:0051482 P:elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger
GO:0001822 P:kidney development
GO:0034374 P:low-density lipoprotein particle remodeling
GO:0032270 P:positive regulation of cellular protein metabolic process
GO:0010873 P:positive regulation of cholesterol esterification
GO:0050729 P:positive regulation of inflammatory response
GO:0010744 P:positive regulation of macrophage derived foam cell differentiation
GO:0033864 P:positive regulation of NAD(P)H oxidase activity
GO:0032430 P:positive regulation of phospholipase A2 activity
GO:2000379 P:positive regulation of reactive oxygen species metabolic process
GO:0002034 P:regulation of blood vessel size by renin-angiotensin
GO:0001558 P:regulation of cell growth
GO:0042127 P:regulation of cell proliferation
GO:0035813 P:regulation of renal sodium excretion
GO:0019229 P:regulation of vasoconstriction
GO:0042312 P:regulation of vasodilation
GO:0002018 P:renin-angiotensin regulation of aldosterone production
GO:0007266 P:Rho protein signal transduction

References (9)

[1] “Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.”  Mauzy C.A.et.al.   1378723
[2] “Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.”  Furuta H.et.al.   1543512
[3] “Cloning and characterization of a human angiotensin II type 1 receptor.”  Bergsma D.J.et.al.   1567413
[4] “Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.”  Takayanagi R.et.al.   1550596
[5] “Genetic analysis of the human type-1 angiotensin II receptor.”  Curnow K.M.et.al.   1508224
[6] “Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression.”  Konishi H.et.al.   8135787
[7] “Type 1 angiotensin II receptors of adrenal tumors.”  Nawata H.et.al.   7792812
[8] “G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.”  Kostenis E.et.al.   15809376
[9] “Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.”  Gribouval O.et.al.   16116425
Structure:
4YAY   4ZUD   6DO1   6OS0   6OS1   6OS2     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 
61:	TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT 
121:	CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC 
181:	AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK 
241:	IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 
301:	FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE