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9.A.14.13.10
The apelin hormone receptor (angiotensin receptor; GPCR APJ; GPCR HC11) of 380 aas.  The human apelin (77 aas) receptor is coupled to G proteins that inhibit adenylate cyclase activity.
It plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. During heart formation, it acts as a receptor for elabela hormone (ELA). It influences cell movement during embryonic development and serves as an alternative coreceptor with CD4 for HIV-1 infection (Pauli et al. 2014); it may be involved in the development of AIDS dementia.

Accession Number:P35414
Protein Name:Apelin receptor
Length:380
Molecular Weight:42660.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Structure:
2LOT   2LOU   2LOV   2LOW     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
61:	RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
121:	TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
181:	CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
241:	RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
301:	NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
361:	GGEQMHEKSI PYSQETLVVD